| Point72 Asset Management, L.P. | 4,432,559 | $36,258 |
| ORBIMED ADVISORS LLC | 3,840,500 | $31,415 |
| VR Adviser, LLC | 3,840,250 | $31,413 |
| Deep Track Capital, LP | 1,854,255 | $15,168 |
| Rosalind Advisors, Inc. | 1,657,540 | $13,559 |
| ACORN CAPITAL ADVISORS, LLC | 1,573,023 | $12,874 |
| MORGAN STANLEY | 1,299,756 | $10,632 |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,257,000 | $10,282 |
| MILLENNIUM MANAGEMENT LLC | 1,028,549 | $8,414 |
| SPHERA FUNDS MANAGEMENT LTD. | 825,576 | $6,753 |
| CITADEL ADVISORS LLC | 805,377 | $6,588 |
| DCF Advisers, LLC | 775,588 | $6,344 |
| Spruce Street Capital LP | 770,000 | $6,299 |
| Boxer Capital Management, LLC | 715,000 | $5,849 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 700,000 | $5,726 |
| ArrowMark Colorado Holdings LLC | 598,419 | $4,895 |
| Squadron Capital Management LLC | 525,000 | $4,295 |
| Nan Fung Group Holdings Ltd | 460,000 | $3,763 |
| DAFNA Capital Management LLC | 455,018 | $3,722 |
| Stonepine Capital Management, LLC | 339,902 | $2,780 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 300,230 | $2,456 |
| Knott David M Jr | 285,182 | $2,333 |
| PEAK6 LLC | 283,507 | $2,776 |
| ADAR1 Capital Management, LLC | 238,390 | $1,950 |
| UBS Group AG | 233,714 | $1,912 |
| Pale Fire Capital SE | 153,505 | $1,256 |
| Ikarian Capital, LLC | 132,153 | $1,081 |
| JANE STREET GROUP, LLC | 99,034 | $810 |
| AdvisorShares Investments LLC | 98,058 | $802 |
| Quadrature Capital Ltd | 79,697 | $652 |
| Fore Capital, LLC | 66,421 | $543 |
| ROYAL BANK OF CANADA | 51,082 | $418 |
| GOLDMAN SACHS GROUP INC | 47,931 | $392 |
| Graham Capital Management, L.P. | 35,509 | $290 |
| PDS Planning, Inc | 30,344 | $248 |
| MYDA Advisors LLC | 30,000 | $245 |
| BOOTHBAY FUND MANAGEMENT, LLC | 29,404 | $241 |
| BlackRock, Inc. | 25,403 | $208 |
| JPMORGAN CHASE & CO | 22,443 | $184 |
| LPL Financial LLC | 18,125 | $148 |
| Diametric Capital, LP | 17,758 | $145 |
| PNC Financial Services Group, Inc. | 11,010 | $90 |
| GROUP ONE TRADING, L.P. | 10,725 | $88 |
| NATIONAL BANK OF CANADA /FI/ | 5,408 | $33 |
| BANK OF AMERICA CORP /DE/ | 4,248 | $35 |
| Federation des caisses Desjardins du Quebec | 3,121 | $25 |
| Global Retirement Partners, LLC | 3,100 | $25 |
| OSAIC HOLDINGS, INC. | 2,928 | $24 |
| IAG Wealth Partners, LLC | 2,750 | $22 |
| Tower Research Capital LLC (TRC) | 2,556 | $21 |
| North Star Investment Management Corp. | 2,500 | $20 |
| TD Waterhouse Canada Inc. | 2,033 | $16 |
| BNP PARIBAS ARBITRAGE, SA | 925 | $8 |
| BARCLAYS PLC | 862 | $7 |
| Global Wealth Strategies & Associates | 526 | $4 |
| HARBOUR INVESTMENTS, INC. | 250 | $2 |
| Farther Finance Advisors, LLC | 247 | $2 |
| IFP Advisors, Inc | 200 | $2 |
| Avalon Trust Co | 197 | $2 |
| Atlantic Edge Private Wealth Management, LLC | 137 | $1 |
| Tidemark, LLC | 131 | $1 |
| AMERIFLEX GROUP, INC. | 131 | $1 |
| Hilton Head Capital Partners, LLC | 117 | $1 |
| FLAGSHIP HARBOR ADVISORS, LLC | 105 | $1 |
| FNY Investment Advisers, LLC | 100 | $0 |
| NewEdge Advisors, LLC | 95 | $1 |
| Root Financial Partners, LLC | 65 | $1 |
| NVWM, LLC | 59 | $0 |
| CENTRAL TRUST Co | 26 | $0 |
| Westside Investment Management, Inc. | 26 | $0 |
| City State Bank | 25 | $0 |
| Larson Financial Group LLC | 21 | $0 |
| Allworth Financial LP | 20 | $0 |
| SRS Capital Advisors, Inc. | 13 | $0 |
| McIlrath & Eck, LLC | 10 | $0 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 7 | $0 |
| CNB Bank | 4 | $0 |
| CoreCap Advisors, LLC | 3 | $0 |
| TSFG, LLC | 2 | $0 |
| MCGUIRE CAPITAL ADVISORS INC | 1 | $0 |