CYNAPSUS THERAPEUTICS INC

CUSIP: 23257Y859 Class: COM PAR NO PAR

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016

Shares 499,999 Value ($000) $20,114 Avg Close — Range —

Q2 2016

Shares 1,140,325 Value ($000) $17,470 Avg Close — Range —

Q1 2016

Shares 1,140,325 Value ($000) $13,221 Avg Close — Range —

Q4 2015

Shares 1,140,325 Value ($000) $17,604 Avg Close — Range —

Q3 2015

Shares 1,140,325 Value ($000) $18,439 Avg Close — Range —

Q2 2015

Shares 1,140,325 Value ($000) $23,274 Avg Close — Range —

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2016	499,999	$20,114	—	—
Q2 2016	1,140,325	$17,470	—	—
Q1 2016	1,140,325	$13,221	—	—
Q4 2015	1,140,325	$17,604	—	—
Q3 2015	1,140,325	$18,439	—	—
Q2 2015	1,140,325	$23,274	—	—