CYNAPSUS THERAPEUTICS INC

CUSIP: 23257Y859 Class: COM PAR NO PAR

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016
Shares 134,037 Value ($000) $2,245 Avg Close — Range —
Q1 2016
Shares 134,037 Value ($000) $1,595 Avg Close — Range —
Q4 2015
Shares 134,037 Value ($000) $2,070 Avg Close — Range —
Q3 2015
Shares 188,930 Value ($000) $3,059 Avg Close — Range —
Q2 2015
Shares 316,448 Value ($000) $5,324 Avg Close — Range —