CYNAPSUS THERAPEUTICS INC

CUSIP: 23257Y859 Class: COM PAR NO PAR

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016
Shares 125,000 Value ($000) $5,029 Avg Close — Range —
Q2 2016
Shares 125,000 Value ($000) $2,094 Avg Close — Range —
Q1 2016
Shares 121,000 Value ($000) $1,440 Avg Close — Range —
Q4 2015
Shares 110,000 Value ($000) $1,682 Avg Close — Range —
Q3 2015
Shares 29,000 Value ($000) $469 Avg Close — Range —