CYTOKINETICS INC

Ticker: CYTK CUSIP: 23282W605 Class: EQTY

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 190,807 Value ($000) $11,959 Avg Close $62.21 Range $53.61 - $70.98

Q3 2025

Shares 191,897 Value ($000) $10,547 Avg Close $41.20 Range $32.66 - $55.92

Q2 2025

Shares 175,279 Value ($000) $5,791 Avg Close $34.78 Range $29.31 - $43.69

Q1 2025

Shares 167,684 Value ($000) $6,739 Avg Close $45.96 Range $39.81 - $52.80

Q4 2024

Shares 188,538 Value ($000) $8,869 Avg Close $51.94 Range $45.66 - $59.39

Q3 2024

Shares 214,832 Value ($000) $11,343 Avg Close $55.74 Range $51.05 - $61.38

Q2 2024

Shares 173,775 Value ($000) $9,415 Avg Close $60.36 Range $46.25 - $75.71

Q1 2024

Shares 153,569 Value ($000) $10,767 Avg Close $77.34 Range $61.33 - $110.25

Q4 2023

Shares 99,410 Value ($000) $8,300 Avg Close $36.21 Range $25.98 - $87.58

Q3 2023

Shares 66,558 Value ($000) $1,961 Avg Close $33.30 Range $28.96 - $37.10

Q2 2023

Shares 69,107 Value ($000) $2,254 Avg Close $37.00 Range $32.32 - $41.24

Q1 2023

Shares 64,929 Value ($000) $2,285 Avg Close $40.80 Range $32.96 - $46.23

Q4 2022

Shares 60,383 Value ($000) $2,763 Avg Close $42.95 Range $35.35 - $52.40

Q3 2022

Shares 59,839 Value ($000) $2,912 Avg Close $48.13 Range $38.16 - $55.80

Q2 2022

Shares 54,280 Value ($000) $2,335 Avg Close $40.26 Range $33.60 - $49.41

Q1 2022

Shares 53,831 Value ($000) $1,976 Avg Close $35.53 Range $29.26 - $46.95

Q4 2021

Shares 39,985 Value ($000) $1,823 Avg Close $38.59 Range $33.41 - $47.90

Q3 2021

Shares 40,694 Value ($000) $1,454 Avg Close $29.44 Range $17.72 - $36.50

Q2 2021

Shares 38,753 Value ($000) $767 Avg Close $23.48 Range $19.52 - $28.12

Q1 2021

Shares 37,744 Value ($000) $878 Avg Close $21.35 Range $18.00 - $25.82

Q4 2020

Shares 40,030 Value ($000) $832 Avg Close $18.28 Range $14.71 - $30.14

Q3 2020

Shares 37,750 Value ($000) $817 Avg Close $23.39 Range $20.17 - $29.20

Q2 2020

Shares 33,551 Value ($000) $791 Avg Close $18.75 Range $10.75 - $25.23

Q1 2020

Shares 36,200 Value ($000) $427 Avg Close $12.76 Range $8.00 - $16.96

Q4 2019

Shares 34,241 Value ($000) $363 Avg Close $10.27 Range $7.73 - $12.35

Q3 2019

Shares 35,331 Value ($000) $403 Avg Close $12.55 Range $10.64 - $14.94

Q2 2019

Shares 35,331 Value ($000) $397 Avg Close $9.64 Range $7.76 - $11.48

Q1 2019

Shares 31,401 Value ($000) $255 Avg Close $7.35 Range $5.75 - $10.44

Q4 2018

Shares 29,989 Value ($000) $189 Avg Close $7.34 Range $5.90 - $9.95

Q3 2018

Shares 32,817 Value ($000) $323 Avg Close $8.02 Range $6.21 - $10.00

Q2 2018

Shares 37,582 Value ($000) $313 Avg Close $8.32 Range $6.75 - $10.00

Q1 2018

Shares 32,907 Value ($000) $237 Avg Close $8.57 Range $7.15 - $10.26

Q4 2017

Shares 33,559 Value ($000) $273 Avg Close $11.35 Range $7.00 - $15.95

Q3 2017

Shares 32,615 Value ($000) $473 Avg Close $13.66 Range $11.78 - $15.33

Q2 2017

Shares 32,708 Value ($000) $395 Avg Close $13.90 Range $11.00 - $17.20

Q1 2017

Shares 27,218 Value ($000) $351 Avg Close $11.69 Range $9.80 - $13.70

Q4 2016

Shares 24,176 Value ($000) $294 Avg Close $10.61 Range $8.77 - $12.75

Q3 2016

Shares 24,578 Value ($000) $225 Avg Close $10.44 Range $8.51 - $12.98

Q2 2016

Shares 25,695 Value ($000) $244 Avg Close $8.21 Range $6.92 - $10.13

Q1 2016

Shares 24,433 Value ($000) $164 Avg Close $7.31 Range $6.00 - $10.71

Q4 2015

Shares 25,313 Value ($000) $264 Avg Close $9.81 Range $6.44 - $13.18

Q3 2015

Shares 25,313 Value ($000) $169 Avg Close $6.83 Range $5.88 - $7.95

Q2 2015

Shares 24,548 Value ($000) $165 Avg Close $6.56 Range $5.50 - $7.59

Q1 2015

Shares 23,793 Value ($000) $161 Avg Close $7.47 Range $6.14 - $8.61

Q4 2014

Shares 25,123 Value ($000) $201 Avg Close $4.29 Range $3.05 - $8.25

Q3 2014

Shares 23,393 Value ($000) $82 Avg Close $4.20 Range $3.49 - $4.99

Q2 2014

Shares 23,393 Value ($000) $111 Avg Close $6.10 Range $3.96 - $13.26

Q1 2014

Shares 20,969 Value ($000) $199 Avg Close $9.04 Range $6.42 - $11.13

Q4 2013

Shares 21,494 Value ($000) $140 Avg Close $6.57 Range $5.99 - $7.72

Q3 2013

Shares 18,894 Value ($000) $143 Avg Close $10.73 Range $7.19 - $14.28

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	190,807	$11,959	$62.21	$53.61 - $70.98
Q3 2025	191,897	$10,547	$41.20	$32.66 - $55.92
Q2 2025	175,279	$5,791	$34.78	$29.31 - $43.69
Q1 2025	167,684	$6,739	$45.96	$39.81 - $52.80
Q4 2024	188,538	$8,869	$51.94	$45.66 - $59.39
Q3 2024	214,832	$11,343	$55.74	$51.05 - $61.38
Q2 2024	173,775	$9,415	$60.36	$46.25 - $75.71
Q1 2024	153,569	$10,767	$77.34	$61.33 - $110.25
Q4 2023	99,410	$8,300	$36.21	$25.98 - $87.58
Q3 2023	66,558	$1,961	$33.30	$28.96 - $37.10
Q2 2023	69,107	$2,254	$37.00	$32.32 - $41.24
Q1 2023	64,929	$2,285	$40.80	$32.96 - $46.23
Q4 2022	60,383	$2,763	$42.95	$35.35 - $52.40
Q3 2022	59,839	$2,912	$48.13	$38.16 - $55.80
Q2 2022	54,280	$2,335	$40.26	$33.60 - $49.41
Q1 2022	53,831	$1,976	$35.53	$29.26 - $46.95
Q4 2021	39,985	$1,823	$38.59	$33.41 - $47.90
Q3 2021	40,694	$1,454	$29.44	$17.72 - $36.50
Q2 2021	38,753	$767	$23.48	$19.52 - $28.12
Q1 2021	37,744	$878	$21.35	$18.00 - $25.82
Q4 2020	40,030	$832	$18.28	$14.71 - $30.14
Q3 2020	37,750	$817	$23.39	$20.17 - $29.20
Q2 2020	33,551	$791	$18.75	$10.75 - $25.23
Q1 2020	36,200	$427	$12.76	$8.00 - $16.96
Q4 2019	34,241	$363	$10.27	$7.73 - $12.35
Q3 2019	35,331	$403	$12.55	$10.64 - $14.94
Q2 2019	35,331	$397	$9.64	$7.76 - $11.48
Q1 2019	31,401	$255	$7.35	$5.75 - $10.44
Q4 2018	29,989	$189	$7.34	$5.90 - $9.95
Q3 2018	32,817	$323	$8.02	$6.21 - $10.00
Q2 2018	37,582	$313	$8.32	$6.75 - $10.00
Q1 2018	32,907	$237	$8.57	$7.15 - $10.26
Q4 2017	33,559	$273	$11.35	$7.00 - $15.95
Q3 2017	32,615	$473	$13.66	$11.78 - $15.33
Q2 2017	32,708	$395	$13.90	$11.00 - $17.20
Q1 2017	27,218	$351	$11.69	$9.80 - $13.70
Q4 2016	24,176	$294	$10.61	$8.77 - $12.75
Q3 2016	24,578	$225	$10.44	$8.51 - $12.98
Q2 2016	25,695	$244	$8.21	$6.92 - $10.13
Q1 2016	24,433	$164	$7.31	$6.00 - $10.71
Q4 2015	25,313	$264	$9.81	$6.44 - $13.18
Q3 2015	25,313	$169	$6.83	$5.88 - $7.95
Q2 2015	24,548	$165	$6.56	$5.50 - $7.59
Q1 2015	23,793	$161	$7.47	$6.14 - $8.61
Q4 2014	25,123	$201	$4.29	$3.05 - $8.25
Q3 2014	23,393	$82	$4.20	$3.49 - $4.99
Q2 2014	23,393	$111	$6.10	$3.96 - $13.26
Q1 2014	20,969	$199	$9.04	$6.42 - $11.13
Q4 2013	21,494	$140	$6.57	$5.99 - $7.72
Q3 2013	18,894	$143	$10.73	$7.19 - $14.28