| BlackRock, Inc. | 16,395,123 | $1,041,746 |
| FMR LLC | 12,807,752 | $813,805 |
| VANGUARD GROUP INC | 12,048,131 | $765,538 |
| T. Rowe Price Investment Management, Inc. | 9,390,404 | $597 |
| WELLINGTON MANAGEMENT GROUP LLP | 7,937,063 | $504,321 |
| STATE STREET CORP | 5,825,295 | $370,139 |
| Deep Track Capital, LP | 3,336,998 | $212,033 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,056,017 | $194,214 |
| BANK OF AMERICA CORP /DE/ | 2,941,152 | $186,881 |
| RTW INVESTMENTS, LP | 2,721,158 | $172,902 |
| Polar Capital Holdings Plc | 2,422,612 | $153,933 |
| GOLDMAN SACHS GROUP INC | 2,371,679 | $150,696 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,930,119 | $123 |
| Woodline Partners LP | 1,648,428 | $104,741 |
| JPMORGAN CHASE & CO | 1,412,797 | $89,769 |
| Integral Health Asset Management, LLC | 1,400,000 | $88,956 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,383,437 | $87,904 |
| NORTHERN TRUST CORP | 1,380,787 | $87,735 |
| MORGAN STANLEY | 1,265,301 | $80,397 |
| Capital International Investors | 1,178,780 | $74,900 |
| CITADEL ADVISORS LLC | 1,162,937 | $73,893 |
| UBS Group AG | 1,131,456 | $71,893 |
| ARMISTICE CAPITAL, LLC | 992,766 | $63,080 |
| PRINCIPAL FINANCIAL GROUP INC | 976,892 | $62,072 |
| Frazier Life Sciences Management, L.P. | 934,642 | $59,387 |
| Bank of New York Mellon Corp | 854,309 | $54,283 |
| BNP Paribas Investment Partners S.A. | 827,863 | $53 |
| Fisher Asset Management, LLC | 822,885 | $52,286 |
| NORGES BANK | 807,070 | $51,281 |
| Affinity Asset Advisors, LLC | 800,000 | $50,832 |
| Pictet Asset Management Holding SA | 757,563 | $48,023 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 753,617 | $47,885 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 747,983 | $47,527 |
| BROWN ADVISORY INC | 731,154 | $46,458 |
| Melqart Asset Management (UK) Ltd | 622,898 | $39,579 |
| BNP PARIBAS ARBITRAGE, SA | 579,862 | $36,844 |
| AMERIPRISE FINANCIAL INC | 545,805 | $34,680 |
| TD Asset Management Inc | 544,010 | $34,566 |
| ADAR1 Capital Management, LLC | 540,166 | $34,322 |
| Qube Research & Technologies Ltd | 537,277 | $34,139 |
| FEDERATED HERMES, INC. | 483,668 | $30,732 |
| abrdn plc | 483,061 | $30,694 |
| EVENTIDE ASSET MANAGEMENT, LLC | 479,611 | $30,473 |
| GW&K Investment Management, LLC | 472,363 | $30 |
| Foresite Capital Management IV, LLC | 458,295 | $29,120 |
| AMERICAN CENTURY COMPANIES INC | 443,910 | $28,206 |
| ALLIANCEBERNSTEIN L.P. | 412,966 | $26,240 |
| FRANKLIN RESOURCES INC | 409,990 | $26,051 |
| GROUP ONE TRADING, L.P. | 407,253 | $25,877 |
| Sarissa Capital Management LP | 396,357 | $25,185 |
| GILDER GAGNON HOWE & CO LLC | 385,820 | $24,515 |
| DAFNA Capital Management LLC | 370,997 | $23,573 |
| Nuveen, LLC | 369,279 | $23,464 |
| E. Ohman J:or Asset Management AB | 362,962 | $23,063 |
| RHUMBLINE ADVISERS | 356,995 | $22,683 |
| BARCLAYS PLC | 343,458 | $21,823 |
| ExodusPoint Capital Management, LP | 343,144 | $21,803 |
| GSK plc | 340,434 | $21,631 |
| MARSHALL WACE, LLP | 337,031 | $21,415 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 327,202 | $20,790 |
| First Turn Management, LLC | 325,668 | $20,693 |
| Logos Global Management LP | 300,000 | $19,062 |
| JANE STREET GROUP, LLC | 284,125 | $18,053 |
| Susquehanna Portfolio Strategies, LLC | 278,429 | $17,691 |
| TWO SIGMA INVESTMENTS, LP | 274,017 | $17,411 |
| Catalio Capital Management, LP | 258,381 | $16,418 |
| JANUS HENDERSON GROUP PLC | 256,212 | $16,283 |
| AQR CAPITAL MANAGEMENT LLC | 236,925 | $14,775 |
| UBS ASSET MANAGEMENT AMERICAS INC | 235,049 | $14,935 |
| MILLENNIUM MANAGEMENT LLC | 225,456 | $14,325 |
| Swiss National Bank | 224,200 | $14,246 |
| Handelsbanken Fonder AB | 205,800 | $13 |
| Invesco Ltd. | 204,878 | $13,018 |
| Mirador Capital Partners LP | 198,558 | $12,616 |
| Rosalind Advisors, Inc. | 195,045 | $12,393 |
| PINNACLE ASSOCIATES LTD | 190,999 | $12,136 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 190,807 | $11,959 |
| SEGALL BRYANT & HAMILL, LLC | 189,513 | $12,042 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 189,401 | $12,035 |
| DEUTSCHE BANK AG\ | 175,804 | $11,171 |
| Hudson Bay Capital Management LP | 175,350 | $11,142 |
| TWO SIGMA ADVISERS, LP | 174,700 | $11,100 |
| Ikarian Capital, LLC | 172,672 | $10,972 |
| RENAISSANCE TECHNOLOGIES LLC | 172,067 | $10,933 |
| Legal & General Group Plc | 168,586 | $10,712 |
| Checkpoint Capital L.P. | 166,823 | $10,600 |
| WELLS FARGO & COMPANY/MN | 161,556 | $10,265 |
| STEMPOINT CAPITAL LP | 146,978 | $9,339 |
| Retirement Systems of Alabama | 146,668 | $9,319 |
| Candriam S.C.A. | 146,631 | $9,317 |
| ROYCE & ASSOCIATES LP | 144,426 | $9,177 |
| Russell Investments Group, Ltd. | 137,690 | $8,749 |
| Hood River Capital Management LLC | 137,597 | $8,743 |
| FIRST TRUST ADVISORS LP | 127,524 | $8,103 |
| Exome Asset Management LLC | 124,749 | $7,927 |
| READYSTATE ASSET MANAGEMENT LP | 122,711 | $7,797 |
| MetLife Investment Management, LLC | 121,910 | $7,746 |
| D. E. Shaw & Co., Inc. | 119,221 | $7,575 |
| HighVista Strategies LLC | 114,564 | $7,279 |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 114,500 | $7 |
| 324 other institutions | 6,066,189 | $353,802 |