| Artisan Partners Limited Partnership | 3,309,055 | $63,435 |
| Vivo Capital, LLC | 2,461,626 | $47,189 |
| Siren, L.L.C. | 1,857,362 | $35,606 |
| BAKER BROS. ADVISORS LP | 1,461,425 | $28,016 |
| MPM BioImpact LLC | 996,825 | $19,109 |
| MILLENNIUM MANAGEMENT LLC | 640,885 | $12,286 |
| Yiheng Capital Management, L.P. | 639,769 | $12,264 |
| Octagon Capital Advisors LP | 574,200 | $11,007 |
| Redmile Group, LLC | 549,840 | $10,540 |
| Ikarian Capital, LLC | 525,000 | $2,084 |
| Schonfeld Strategic Advisors LLC | 454,343 | $8,710 |
| Patient Square Capital LP | 359,050 | $6,883 |
| Vestal Point Capital, LP | 300,000 | $5,751 |
| UBS Group AG | 244,862 | $4,694 |
| Squadron Capital Management LLC | 240,000 | $4,601 |
| BALYASNY ASSET MANAGEMENT L.P. | 235,023 | $4,505 |
| NEW YORK STATE COMMON RETIREMENT FUND | 223,186 | $4,278 |
| Atika Capital Management LLC | 206,881 | $3,966 |
| BOOTHBAY FUND MANAGEMENT, LLC | 163,401 | $3,132 |
| CITADEL ADVISORS LLC | 145,129 | $2,782 |
| MORGAN STANLEY | 122,495 | $2,348 |
| SEI INVESTMENTS CO | 66,341 | $1,272 |
| Polymer Capital Management (HK) LTD | 64,500 | $1,236 |
| Optiver Holding B.V. | 47,728 | $915 |
| NAN FUNG TRINITY (HK) LTD | 37,095 | $711 |
| TWO SIGMA INVESTMENTS, LP | 33,947 | $651 |
| JPMORGAN CHASE & CO | 28,379 | $544 |
| ExodusPoint Capital Management, LP | 27,211 | $522 |
| Logos Global Management LP | 25,000 | $479 |
| Engineers Gate Manager LP | 24,984 | $479 |
| ENVESTNET ASSET MANAGEMENT INC | 22,392 | $429 |
| MARSHALL WACE, LLP | 20,961 | $402 |
| HighVista Strategies LLC | 15,877 | $304 |
| Qube Research & Technologies Ltd | 13,736 | $263 |
| Cetera Investment Advisers | 13,115 | $251 |
| RHUMBLINE ADVISERS | 6,433 | $123 |
| Persistent Asset Partners Ltd | 6,019 | $115 |
| Truvestments Capital LLC | 3,892 | $75 |
| GAMMA Investing LLC | 2,680 | $51 |
| ROYAL BANK OF CANADA | 1,752 | $34 |
| Allworth Financial LP | 1,683 | $32 |
| EverSource Wealth Advisors, LLC | 479 | $9 |
| OSAIC HOLDINGS, INC. | 343 | $7 |
| WELLS FARGO & COMPANY/MN | 300 | $6 |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 300 | $6 |
| BANK OF AMERICA CORP /DE/ | 257 | $5 |
| Federation des caisses Desjardins du Quebec | 145 | $3 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 111 | $2 |
| Pinnacle Wealth Planning Services, Inc. | 40 | $1 |
| CURIO WEALTH, LLC | 27 | $1 |
| TRUST CO OF TOLEDO NA /OH/ | 10 | $0 |
| BlackRock, Inc. | 2 | $0 |