DENALI THERAPEUTICS INC

Ticker: DNLI CUSIP: 24823R105 Class: Common Stock

MILLENNIUM MANAGEMENT LLC's Holding History (CIK: 0001273087)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 369,767 Value ($000) $6,105 Avg Close $16.88 Range $13.75 - $20.61

Q3 2025

Shares 1,307,171 Value ($000) $18,980 Avg Close $14.37 Range $12.58 - $16.20

Q2 2025

Shares 900,501 Value ($000) $12,598 Avg Close $14.07 Range $10.57 - $16.97

Q1 2025

Shares 1,493,068 Value ($000) $20,298 Avg Close $19.16 Range $13.30 - $24.34

Q4 2024

Shares 404,224 Value ($000) $8,238 Avg Close $25.60 Range $19.93 - $33.33

Q3 2024

Shares 60,168 Value ($000) $1,753 Avg Close $24.79 Range $19.74 - $32.13

Q2 2024

Shares 619,929 Value ($000) $14,395 Avg Close $19.20 Range $14.56 - $23.87

Q1 2024

Shares 390,616 Value ($000) $8,015 Avg Close $18.79 Range $15.49 - $23.52

Q3 2023

Shares 118,351 Value ($000) $2,442 Avg Close $25.37 Range $20.52 - $30.79

Q2 2023

Shares 478,186 Value ($000) $14,111 Avg Close $28.12 Range $22.72 - $33.31

Q1 2023

Shares 386,289 Value ($000) $9 Avg Close $27.52 Range $21.74 - $32.81

Q4 2022

Shares 297,093 Value ($000) $8 Avg Close $29.75 Range $25.96 - $34.78

Q3 2022

Shares 496,184 Value ($000) $15,228 Avg Close $32.51 Range $25.88 - $39.43

Q2 2022

Shares 645,336 Value ($000) $18,992 Avg Close $26.20 Range $20.24 - $35.62

Q4 2021

Shares 18,360 Value ($000) $819 Avg Close $47.38 Range $41.10 - $56.08

Q3 2021

Shares 41,842 Value ($000) $2,111 Avg Close $56.36 Range $47.02 - $79.50

Q2 2021

Shares 19,443 Value ($000) $1,525 Avg Close $61.86 Range $49.20 - $79.70

Q1 2021

Shares 14,712 Value ($000) $840 Avg Close $66.94 Range $52.23 - $84.25

Q4 2020

Shares 5,814 Value ($000) $487 Avg Close $60.45 Range $35.89 - $93.94

Q3 2020

Shares 127,688 Value ($000) $4,575 Avg Close $30.12 Range $22.36 - $39.22

Q2 2020

Shares 22,309 Value ($000) $539 Avg Close $23.51 Range $15.72 - $29.39

Q3 2019

Shares 101,659 Value ($000) $1,557 Avg Close $19.11 Range $15.29 - $22.26

Q1 2019

Shares 34,451 Value ($000) $800 Avg Close $20.92 Range $17.73 - $25.05

Q2 2018

Shares 171,979 Value ($000) $2,623 Avg Close $18.84 Range $15.19 - $22.99

Q4 2017

Shares 94,316 Value ($000) $1,475 Avg Close $17.97 Range $14.72 - $22.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	369,767	$6,105	$16.88	$13.75 - $20.61
Q3 2025	1,307,171	$18,980	$14.37	$12.58 - $16.20
Q2 2025	900,501	$12,598	$14.07	$10.57 - $16.97
Q1 2025	1,493,068	$20,298	$19.16	$13.30 - $24.34
Q4 2024	404,224	$8,238	$25.60	$19.93 - $33.33
Q3 2024	60,168	$1,753	$24.79	$19.74 - $32.13
Q2 2024	619,929	$14,395	$19.20	$14.56 - $23.87
Q1 2024	390,616	$8,015	$18.79	$15.49 - $23.52
Q3 2023	118,351	$2,442	$25.37	$20.52 - $30.79
Q2 2023	478,186	$14,111	$28.12	$22.72 - $33.31
Q1 2023	386,289	$9	$27.52	$21.74 - $32.81
Q4 2022	297,093	$8	$29.75	$25.96 - $34.78
Q3 2022	496,184	$15,228	$32.51	$25.88 - $39.43
Q2 2022	645,336	$18,992	$26.20	$20.24 - $35.62
Q4 2021	18,360	$819	$47.38	$41.10 - $56.08
Q3 2021	41,842	$2,111	$56.36	$47.02 - $79.50
Q2 2021	19,443	$1,525	$61.86	$49.20 - $79.70
Q1 2021	14,712	$840	$66.94	$52.23 - $84.25
Q4 2020	5,814	$487	$60.45	$35.89 - $93.94
Q3 2020	127,688	$4,575	$30.12	$22.36 - $39.22
Q2 2020	22,309	$539	$23.51	$15.72 - $29.39
Q3 2019	101,659	$1,557	$19.11	$15.29 - $22.26
Q1 2019	34,451	$800	$20.92	$17.73 - $25.05
Q2 2018	171,979	$2,623	$18.84	$15.19 - $22.99
Q4 2017	94,316	$1,475	$17.97	$14.72 - $22.95