| VANGUARD GROUP INC | 13,057,890 | $215,586 |
| BlackRock, Inc. | 12,715,201 | $209,928 |
| BAILLIE GIFFORD & CO | 12,310,889 | $203,253 |
| Temasek Holdings (Private) Ltd | 7,012,974 | $115,784 |
| STATE STREET CORP | 6,263,371 | $103,408 |
| FMR LLC | 6,097,211 | $100,665 |
| NORGES BANK | 5,119,622 | $84,525 |
| UBS ASSET MANAGEMENT AMERICAS INC | 4,983,726 | $82,281 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,915,951 | $65 |
| GOLDMAN SACHS GROUP INC | 3,835,803 | $63,329 |
| BAKER BROS. ADVISORS LP | 3,731,695 | $61,610 |
| Capital Research Global Investors | 3,729,244 | $61,570 |
| ALLIANCEBERNSTEIN L.P. | 3,557,935 | $58,742 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,458,131 | $57,104 |
| Holocene Advisors, LP | 3,152,734 | $52,052 |
| Crestline Management, LP | 2,810,732 | $46,405 |
| Fisher Asset Management, LLC | 2,589,403 | $42,751 |
| UBS Group AG | 2,404,704 | $39,702 |
| DIMENSIONAL FUND ADVISORS LP | 2,374,303 | $39,198 |
| abrdn plc | 2,032,967 | $33,564 |
| Casdin Capital, LLC | 1,840,000 | $30,378 |
| Lynx1 Capital Management LP | 1,738,750 | $28,707 |
| Point72 Asset Management, L.P. | 1,700,000 | $28,067 |
| PRINCIPAL FINANCIAL GROUP INC | 1,524,123 | $25,163 |
| Siren, L.L.C. | 1,396,513 | $23,056 |
| Pictet Asset Management Holding SA | 1,329,108 | $21,981 |
| T. Rowe Price Investment Management, Inc. | 1,245,994 | $21 |
| MORGAN STANLEY | 1,219,854 | $20,140 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,200,475 | $19,820 |
| NORTHERN TRUST CORP | 1,199,744 | $19,808 |
| Candriam S.C.A. | 1,166,379 | $19,258 |
| ExodusPoint Capital Management, LP | 1,023,253 | $16,894 |
| MASTERS CAPITAL MANAGEMENT LLC | 1,000,000 | $16,510 |
| Foresite Capital Management VI LLC | 1,000,000 | $16,510 |
| BANK OF AMERICA CORP /DE/ | 932,144 | $15,390 |
| Alyeska Investment Group, L.P. | 859,108 | $14,184 |
| CITADEL ADVISORS LLC | 779,148 | $12,864 |
| MARSHALL WACE, LLP | 763,892 | $12,612 |
| Bank of New York Mellon Corp | 762,087 | $12,582 |
| Defilade Capital Management, L.P. | 656,713 | $10,842 |
| Palo Alto Investors LP | 641,239 | $10,587 |
| Cercano Management LLC | 625,000 | $10,319 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 591,461 | $9,765 |
| Qube Research & Technologies Ltd | 590,314 | $9,746 |
| SEGALL BRYANT & HAMILL, LLC | 537,000 | $8,866 |
| Ensign Peak Advisors, Inc | 515,721 | $8,515 |
| Vestal Point Capital, LP | 465,000 | $7,677 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 450,985 | $7,401 |
| Hudson Bay Capital Management LP | 450,000 | $7,430 |
| TWO SIGMA INVESTMENTS, LP | 430,177 | $7,102 |
| STEMPOINT CAPITAL LP | 419,058 | $6,919 |
| BARCLAYS PLC | 407,359 | $6,725 |
| AMERICAN CENTURY COMPANIES INC | 379,051 | $6,258 |
| MILLENNIUM MANAGEMENT LLC | 369,767 | $6,105 |
| Clarius Group, LLC | 368,995 | $6,092 |
| TD Asset Management Inc | 339,410 | $5,604 |
| DAFNA Capital Management LLC | 318,500 | $5,258 |
| BNP Paribas Investment Partners S.A. | 298,792 | $5 |
| Invesco Ltd. | 291,936 | $4,820 |
| Marex Group plc | 287,001 | $4,738 |
| Nuveen, LLC | 275,508 | $4,549 |
| Swiss National Bank | 273,800 | $4,520 |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 225,680 | $3,726 |
| Trexquant Investment LP | 209,609 | $3,461 |
| Burkehill Global Management, LP | 200,000 | $3,302 |
| SCS Capital Management LLC | 197,998 | $3,269 |
| WELLS FARGO & COMPANY/MN | 193,681 | $3,198 |
| Rafferty Asset Management, LLC | 191,567 | $3,163 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 184,238 | $3,030 |
| RHUMBLINE ADVISERS | 183,000 | $3,021 |
| AMERIPRISE FINANCIAL INC | 180,221 | $2,975 |
| JPMORGAN CHASE & CO | 171,948 | $2,839 |
| Susquehanna Portfolio Strategies, LLC | 167,713 | $2,769 |
| TWO SIGMA ADVISERS, LP | 154,800 | $2,556 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 153,781 | $3 |
| GROUPAMA ASSET MANAGMENT | 151,591 | $2,503 |
| SG Americas Securities, LLC | 149,592 | $2 |
| Legal & General Group Plc | 131,223 | $2,166 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 129,409 | $2,137 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 128,800 | $2,125 |
| ALGERT GLOBAL LLC | 127,030 | $2 |
| ALPS ADVISORS INC | 120,718 | $1,993 |
| Woodline Partners LP | 114,082 | $1,883 |
| B. Metzler seel. Sohn & Co. AG | 112,300 | $1,841 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 107,493 | $1,775 |
| D.A. DAVIDSON & CO. | 106,933 | $1,765 |
| DEUTSCHE BANK AG\ | 105,086 | $1,735 |
| Rhenman & Partners Asset Management AB | 100,000 | $1,651 |
| Ghisallo Capital Management LLC | 100,000 | $1,651 |
| Integrated Wealth Concepts LLC | 94,582 | $1,562 |
| Y-Intercept (Hong Kong) Ltd | 93,587 | $1,545 |
| Monashee Investment Management LLC | 91,620 | $1,513 |
| HRT FINANCIAL LP | 78,352 | $1 |
| MetLife Investment Management, LLC | 75,164 | $1,241 |
| STATE OF WISCONSIN INVESTMENT BOARD | 73,581 | $1,215 |
| PROFUND ADVISORS LLC | 71,634 | $1,183 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 70,830 | $1,169 |
| Ishara Investments LP | 70,000 | $1,156 |
| PIER 88 INVESTMENT PARTNERS LLC | 68,200 | $1,126 |
| 1492 Capital Management LLC | 67,487 | $1,114 |
| 149 other institutions | 2,364,230 | $34,909 |