DENALI THERAPEUTICS INC

Ticker: DNLI CUSIP: 24823R105 Class: Common Stock

Palo Alto Investors LP's Holding History (CIK: 0001306923)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 641,239 Value ($000) $10,587 Avg Close $16.88 Range $13.75 - $20.61

Q3 2025

Shares 408,006 Value ($000) $5,924 Avg Close $14.37 Range $12.58 - $16.20

Q2 2025

Shares 239,809 Value ($000) $3,355 Avg Close $14.07 Range $10.57 - $16.97

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	641,239	$10,587	$16.88	$13.75 - $20.61
Q3 2025	408,006	$5,924	$14.37	$12.58 - $16.20
Q2 2025	239,809	$3,355	$14.07	$10.57 - $16.97