DENALI THERAPEUTICS INC

Ticker: DNLI CUSIP: 24823R105 Class: Common Stock

MARSHALL WACE, LLP's Holding History (CIK: 0001318757)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 763,892 Value ($000) $12,612 Avg Close $16.88 Range $13.75 - $20.61

Q3 2025

Shares 787,029 Value ($000) $11,428 Avg Close $14.37 Range $12.58 - $16.20

Q2 2025

Shares 1,405,250 Value ($000) $19,659 Avg Close $14.07 Range $10.57 - $16.97

Q1 2025

Shares 2,188,422 Value ($000) $29,763 Avg Close $19.16 Range $13.30 - $24.34

Q4 2024

Shares 1,788,737 Value ($000) $36,454 Avg Close $25.60 Range $19.93 - $33.33

Q3 2024

Shares 1,967,141 Value ($000) $57,303 Avg Close $24.79 Range $19.74 - $32.13

Q2 2024

Shares 2,418,833 Value ($000) $56,165 Avg Close $19.20 Range $14.56 - $23.87

Q1 2024

Shares 2,146,379 Value ($000) $44,044 Avg Close $18.79 Range $15.49 - $23.52

Q4 2023

Shares 1,667,397 Value ($000) $35,782 Avg Close $19.81 Range $15.45 - $23.81

Q1 2023

Shares 350,539 Value ($000) $8,076 Avg Close $27.52 Range $21.74 - $32.81

Q4 2022

Shares 960,639 Value ($000) $26,715 Avg Close $29.75 Range $25.96 - $34.78

Q3 2022

Shares 675,870 Value ($000) $20,744 Avg Close $32.51 Range $25.88 - $39.43

Q2 2022

Shares 817,650 Value ($000) $24,063 Avg Close $26.20 Range $20.24 - $35.62

Q1 2022

Shares 152,855 Value ($000) $4,918 Avg Close $34.41 Range $28.76 - $47.47

Q4 2021

Shares 383,944 Value ($000) $17,123 Avg Close $47.38 Range $41.10 - $56.08

Q3 2021

Shares 531,358 Value ($000) $26,808 Avg Close $56.36 Range $47.02 - $79.50

Q2 2021

Shares 645,999 Value ($000) $50,672 Avg Close $61.86 Range $49.20 - $79.70

Q1 2021

Shares 99,518 Value ($000) $5,682 Avg Close $66.94 Range $52.23 - $84.25

Q3 2020

Shares 325,168 Value ($000) $11,651 Avg Close $30.12 Range $22.36 - $39.22

Q2 2020

Shares 38,570 Value ($000) $933 Avg Close $23.51 Range $15.72 - $29.39

Q1 2020

Shares 242,120 Value ($000) $4,239 Avg Close $20.86 Range $12.39 - $30.41

Q4 2019

Shares 46,377 Value ($000) $808 Avg Close $16.65 Range $14.24 - $20.17

Q1 2019

Shares 15,473 Value ($000) $359 Avg Close $20.92 Range $17.73 - $25.05

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	763,892	$12,612	$16.88	$13.75 - $20.61
Q3 2025	787,029	$11,428	$14.37	$12.58 - $16.20
Q2 2025	1,405,250	$19,659	$14.07	$10.57 - $16.97
Q1 2025	2,188,422	$29,763	$19.16	$13.30 - $24.34
Q4 2024	1,788,737	$36,454	$25.60	$19.93 - $33.33
Q3 2024	1,967,141	$57,303	$24.79	$19.74 - $32.13
Q2 2024	2,418,833	$56,165	$19.20	$14.56 - $23.87
Q1 2024	2,146,379	$44,044	$18.79	$15.49 - $23.52
Q4 2023	1,667,397	$35,782	$19.81	$15.45 - $23.81
Q1 2023	350,539	$8,076	$27.52	$21.74 - $32.81
Q4 2022	960,639	$26,715	$29.75	$25.96 - $34.78
Q3 2022	675,870	$20,744	$32.51	$25.88 - $39.43
Q2 2022	817,650	$24,063	$26.20	$20.24 - $35.62
Q1 2022	152,855	$4,918	$34.41	$28.76 - $47.47
Q4 2021	383,944	$17,123	$47.38	$41.10 - $56.08
Q3 2021	531,358	$26,808	$56.36	$47.02 - $79.50
Q2 2021	645,999	$50,672	$61.86	$49.20 - $79.70
Q1 2021	99,518	$5,682	$66.94	$52.23 - $84.25
Q3 2020	325,168	$11,651	$30.12	$22.36 - $39.22
Q2 2020	38,570	$933	$23.51	$15.72 - $29.39
Q1 2020	242,120	$4,239	$20.86	$12.39 - $30.41
Q4 2019	46,377	$808	$16.65	$14.24 - $20.17
Q1 2019	15,473	$359	$20.92	$17.73 - $25.05