DENALI THERAPEUTICS INC

Ticker: DNLI CUSIP: 24823R105 Class: Common Stock

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2022

Shares 12,306 Value ($000) $342 Avg Close $29.75 Range $25.96 - $34.78

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2022	12,306	$342	$29.75	$25.96 - $34.78