DENALI THERAPEUTICS INC

Ticker: DNLI CUSIP: 24823R105 Class: Common Stock

JANE STREET GROUP, LLC's Holding History (CIK: 0001595888)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 42,922 Value ($000) $709 Avg Close $16.88 Range $13.75 - $20.61

Q3 2025

Shares 224,903 Value ($000) $3,266 Avg Close $14.37 Range $12.58 - $16.20

Q2 2025

Shares 85,332 Value ($000) $1,194 Avg Close $14.07 Range $10.57 - $16.97

Q1 2025

Shares 213,673 Value ($000) $2,905 Avg Close $19.16 Range $13.30 - $24.34

Q4 2024

Shares 229,165 Value ($000) $4,670 Avg Close $25.60 Range $19.93 - $33.33

Q3 2024

Shares 369,671 Value ($000) $10,769 Avg Close $24.79 Range $19.74 - $32.13

Q2 2024

Shares 231,364 Value ($000) $5,372 Avg Close $19.20 Range $14.56 - $23.87

Q1 2024

Shares 48,716 Value ($000) $1,000 Avg Close $18.79 Range $15.49 - $23.52

Q4 2023

Shares 148,965 Value ($000) $3,197 Avg Close $19.81 Range $15.45 - $23.81

Q3 2023

Shares 38,739 Value ($000) $799 Avg Close $25.37 Range $20.52 - $30.79

Q2 2023

Shares 72,800 Value ($000) $2,148 Avg Close $28.12 Range $22.72 - $33.31

Q1 2023

Shares 115,805 Value ($000) $2,668 Avg Close $27.52 Range $21.74 - $32.81

Q4 2022

Shares 14,969 Value ($000) $416 Avg Close $29.75 Range $25.96 - $34.78

Q2 2022

Shares 13,923 Value ($000) $410 Avg Close $26.20 Range $20.24 - $35.62

Q4 2021

Shares 24,456 Value ($000) $1,091 Avg Close $47.38 Range $41.10 - $56.08

Q3 2021

Shares 18,697 Value ($000) $943 Avg Close $56.36 Range $47.02 - $79.50

Q2 2021

Shares 4,313 Value ($000) $338 Avg Close $61.86 Range $49.20 - $79.70

Q1 2021

Shares 12,981 Value ($000) $741 Avg Close $66.94 Range $52.23 - $84.25

Q4 2020

Shares 32,594 Value ($000) $2,731 Avg Close $60.45 Range $35.89 - $93.94

Q3 2020

Shares 29,846 Value ($000) $1,070 Avg Close $30.12 Range $22.36 - $39.22

Q2 2020

Shares 22,927 Value ($000) $554 Avg Close $23.51 Range $15.72 - $29.39

Q1 2020

Shares 38,966 Value ($000) $683 Avg Close $20.86 Range $12.39 - $30.41

Q3 2019

Shares 12,976 Value ($000) $199 Avg Close $19.11 Range $15.29 - $22.26

Q3 2018

Shares 10,020 Value ($000) $218 Avg Close $16.54 Range $12.32 - $21.89

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	42,922	$709	$16.88	$13.75 - $20.61
Q3 2025	224,903	$3,266	$14.37	$12.58 - $16.20
Q2 2025	85,332	$1,194	$14.07	$10.57 - $16.97
Q1 2025	213,673	$2,905	$19.16	$13.30 - $24.34
Q4 2024	229,165	$4,670	$25.60	$19.93 - $33.33
Q3 2024	369,671	$10,769	$24.79	$19.74 - $32.13
Q2 2024	231,364	$5,372	$19.20	$14.56 - $23.87
Q1 2024	48,716	$1,000	$18.79	$15.49 - $23.52
Q4 2023	148,965	$3,197	$19.81	$15.45 - $23.81
Q3 2023	38,739	$799	$25.37	$20.52 - $30.79
Q2 2023	72,800	$2,148	$28.12	$22.72 - $33.31
Q1 2023	115,805	$2,668	$27.52	$21.74 - $32.81
Q4 2022	14,969	$416	$29.75	$25.96 - $34.78
Q2 2022	13,923	$410	$26.20	$20.24 - $35.62
Q4 2021	24,456	$1,091	$47.38	$41.10 - $56.08
Q3 2021	18,697	$943	$56.36	$47.02 - $79.50
Q2 2021	4,313	$338	$61.86	$49.20 - $79.70
Q1 2021	12,981	$741	$66.94	$52.23 - $84.25
Q4 2020	32,594	$2,731	$60.45	$35.89 - $93.94
Q3 2020	29,846	$1,070	$30.12	$22.36 - $39.22
Q2 2020	22,927	$554	$23.51	$15.72 - $29.39
Q1 2020	38,966	$683	$20.86	$12.39 - $30.41
Q3 2019	12,976	$199	$19.11	$15.29 - $22.26
Q3 2018	10,020	$218	$16.54	$12.32 - $21.89