DESIGN THERAPEUTICS INC

Ticker: DSGN CUSIP: 25056L103 Class: Common Stock

MARSHALL WACE, LLP's Holding History (CIK: 0001318757)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 225,528 Value ($000) $2,115 Avg Close $7.83 Range $5.28 - $10.31

Q3 2024

Shares 17,192 Value ($000) $92 Avg Close $4.70 Range $3.15 - $6.91

Q2 2024

Shares 24,280 Value ($000) $81 Avg Close $3.90 Range $3.17 - $5.23

Q3 2023

Shares 60,542 Value ($000) $143 Avg Close $4.66 Range $1.94 - $8.31

Q2 2023

Shares 112,922 Value ($000) $711 Avg Close $6.12 Range $4.90 - $8.47

Q1 2023

Shares 180,919 Value ($000) $1,044 Avg Close $7.48 Range $5.49 - $10.72

Q4 2022

Shares 112,818 Value ($000) $1,158 Avg Close $13.55 Range $6.94 - $17.48

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	225,528	$2,115	$7.83	$5.28 - $10.31
Q3 2024	17,192	$92	$4.70	$3.15 - $6.91
Q2 2024	24,280	$81	$3.90	$3.17 - $5.23
Q3 2023	60,542	$143	$4.66	$1.94 - $8.31
Q2 2023	112,922	$711	$6.12	$4.90 - $8.47
Q1 2023	180,919	$1,044	$7.48	$5.49 - $10.72
Q4 2022	112,818	$1,158	$13.55	$6.94 - $17.48