| SR ONE CAPITAL MANAGEMENT, LP | 6,526,476 | $61,218 |
| Point72 Asset Management, L.P. | 5,372,004 | $50,389 |
| Logos Global Management LP | 2,500,000 | $23,450 |
| BAKER BROS. ADVISORS LP | 2,233,099 | $20,946 |
| BlackRock, Inc. | 2,117,156 | $19,859 |
| VANGUARD GROUP INC | 1,630,910 | $15,298 |
| Vivo Capital, LLC | 1,612,903 | $15,129 |
| Almitas Capital LLC | 1,530,435 | $14,355 |
| RA CAPITAL MANAGEMENT, L.P. | 1,461,381 | $13,708 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,179,817 | $11,067 |
| Woodline Partners LP | 944,039 | $8,855 |
| Kynam Capital Management, LP | 784,606 | $7,360 |
| FMR LLC | 771,268 | $7,234 |
| MORGAN STANLEY | 702,306 | $6,588 |
| GEODE CAPITAL MANAGEMENT, LLC | 679,590 | $6,376 |
| STATE STREET CORP | 647,636 | $6,075 |
| ACADIAN ASSET MANAGEMENT LLC | 612,768 | $6 |
| Frazier Life Sciences Management, L.P. | 521,000 | $4,887 |
| CITADEL ADVISORS LLC | 459,874 | $4,314 |
| D. E. Shaw & Co., Inc. | 438,894 | $4,117 |
| Invesco Ltd. | 305,757 | $2,868 |
| DIMENSIONAL FUND ADVISORS LP | 297,921 | $2,795 |
| RENAISSANCE TECHNOLOGIES LLC | 287,100 | $2,693 |
| NORTHERN TRUST CORP | 286,572 | $2,688 |
| GOLDMAN SACHS GROUP INC | 270,654 | $2,539 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 236,863 | $2,222 |
| JANE STREET GROUP, LLC | 226,512 | $2,125 |
| MARSHALL WACE, LLP | 225,528 | $2,115 |
| Elmind Capital, LP | 207,900 | $1,950 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 194,611 | $1,825 |
| ALGERT GLOBAL LLC | 187,769 | $2 |
| MILLENNIUM MANAGEMENT LLC | 180,866 | $1,697 |
| AMERIPRISE FINANCIAL INC | 158,383 | $1,486 |
| ACUTA CAPITAL PARTNERS, LLC | 150,906 | $1,415 |
| Nuveen, LLC | 125,260 | $1,175 |
| RAYMOND JAMES FINANCIAL INC | 109,763 | $1,030 |
| DIADEMA PARTNERS LP | 100,320 | $941 |
| Trexquant Investment LP | 99,967 | $938 |
| BNP PARIBAS ARBITRAGE, SA | 94,828 | $889 |
| BARCLAYS PLC | 87,060 | $817 |
| Bank of New York Mellon Corp | 84,975 | $797 |
| EAM Investors, LLC | 78,949 | $741 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 78,500 | $736 |
| Lynx1 Capital Management LP | 69,516 | $652 |
| Palumbo Wealth Management LLC | 69,377 | $651 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,852 | $580 |
| AMERICAN CENTURY COMPANIES INC | 57,798 | $542 |
| CANADA PENSION PLAN INVESTMENT BOARD | 54,600 | $512 |
| SEI INVESTMENTS CO | 52,730 | $495 |
| STATE OF WISCONSIN INVESTMENT BOARD | 50,657 | $475 |
| KENNEDY CAPITAL MANAGEMENT LLC | 50,023 | $469 |
| ALPS ADVISORS INC | 46,771 | $439 |
| TWO SIGMA INVESTMENTS, LP | 46,237 | $434 |
| Squarepoint Ops LLC | 46,142 | $433 |
| ALLIANCEBERNSTEIN L.P. | 46,120 | $433 |
| PRUDENTIAL FINANCIAL INC | 42,710 | $401 |
| XTX Topco Ltd | 35,284 | $331 |
| Persistent Asset Partners Ltd | 34,989 | $328 |
| RHUMBLINE ADVISERS | 34,778 | $326 |
| China Universal Asset Management Co., Ltd. | 34,282 | $322 |
| BANK OF AMERICA CORP /DE/ | 27,446 | $257 |
| Corient Private Wealth LLC | 26,965 | $253 |
| WELLS FARGO & COMPANY/MN | 26,786 | $251 |
| UBS Group AG | 25,537 | $240 |
| TWO SIGMA ADVISERS, LP | 25,300 | $237 |
| Russell Investments Group, Ltd. | 25,234 | $237 |
| STRS OHIO | 25,200 | $236 |
| Virtu Financial LLC | 22,651 | $0 |
| AlphaCentric Advisors LLC | 20,262 | $190 |
| Baader Bank Aktiengesellschaft | 20,000 | $188 |
| Velan Capital Investment Management LP | 20,000 | $188 |
| 9823 Capital, L.P. | 19,197 | $180 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,711 | $0 |
| DEUTSCHE BANK AG\ | 15,541 | $146 |
| MetLife Investment Management, LLC | 15,249 | $143 |
| JPMORGAN CHASE & CO | 14,451 | $136 |
| Engineers Gate Manager LP | 14,012 | $131 |
| AQR CAPITAL MANAGEMENT LLC | 13,730 | $129 |
| Mariner, LLC | 12,822 | $120 |
| NISA INVESTMENT ADVISORS, LLC | 11,824 | $111 |
| AXQ CAPITAL, LP | 11,728 | $110 |
| TWO SIGMA SECURITIES, LLC | 11,396 | $107 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,091 | $104 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 7,093 | $67 |
| Police & Firemen's Retirement System of New Jersey | 6,598 | $62 |
| Tower Research Capital LLC (TRC) | 4,273 | $40 |
| CAZ INVESTMENTS LP | 3,500 | $33 |
| CITIGROUP INC | 3,113 | $29 |
| Torren Management, LLC | 2,820 | $26 |
| Mirae Asset Global Investments Co., Ltd. | 2,768 | $26 |
| Ameritas Investment Partners, Inc. | 2,570 | $24 |
| Legal & General Group Plc | 2,077 | $19 |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,026 | $19 |
| PNC Financial Services Group, Inc. | 1,816 | $17 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,471 | $14 |
| Sterling Capital Management LLC | 1,377 | $13 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,227 | $12 |
| GF FUND MANAGEMENT CO. LTD. | 1,118 | $10 |
| AMALGAMATED BANK | 751 | $0 |
| GAMMA Investing LLC | 750 | $7 |
| 17 other institutions | 4,559 | $39 |