DESIGN THERAPEUTICS INC

Ticker: DSGN CUSIP: 25056L103 Class: Common Stock

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 11,396 Value ($000) $107 Avg Close $7.83 Range $5.28 - $10.31

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	11,396	$107	$7.83	$5.28 - $10.31