| FMR LLC | 6,431,329 | $265,035 |
| WELLINGTON MANAGEMENT GROUP LLP | 2,503,190 | $103,156 |
| Octagon Capital Advisors LP | 2,416,667 | $99,591 |
| Fairmount Funds Management LLC | 2,137,191 | $88,074 |
| Avidity Partners Management LP | 2,104,184 | $86,713 |
| VANGUARD GROUP INC | 2,048,452 | $84,417 |
| BlackRock, Inc. | 1,915,236 | $78,927 |
| TCG Crossover Management, LLC | 1,676,624 | $69,094 |
| RA CAPITAL MANAGEMENT, L.P. | 1,611,733 | $66,420 |
| STATE STREET CORP | 1,507,619 | $62,129 |
| BRAIDWELL LP | 1,273,935 | $52,499 |
| Point72 Asset Management, L.P. | 1,166,088 | $48,054 |
| CITADEL ADVISORS LLC | 1,068,934 | $44,051 |
| MARSHALL WACE, LLP | 1,008,533 | $41,562 |
| Polar Capital Holdings Plc | 1,004,728 | $41,405 |
| VR Adviser, LLC | 1,000,000 | $41,210 |
| ALLIANCEBERNSTEIN L.P. | 834,383 | $34,385 |
| BAKER BROS. ADVISORS LP | 789,759 | $32,546 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 750,136 | $30,913 |
| Bain Capital Life Sciences Investors, LLC | 743,592 | $30,643 |
| GEODE CAPITAL MANAGEMENT, LLC | 676,658 | $27,890 |
| MILLENNIUM MANAGEMENT LLC | 667,216 | $27,496 |
| Catalio Capital Management, LP | 653,572 | $26,934 |
| Tri Locum Partners LP | 622,403 | $25,649 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 616,033 | $25 |
| UBS Group AG | 606,620 | $24,999 |
| GOLDMAN SACHS GROUP INC | 577,019 | $23,779 |
| BNP PARIBAS ARBITRAGE, SA | 475,749 | $19,606 |
| Sio Capital Management, LLC | 474,503 | $19,554 |
| BANK OF AMERICA CORP /DE/ | 465,538 | $19,185 |
| FRANKLIN RESOURCES INC | 462,826 | $19,073 |
| Nantahala Capital Management, LLC | 375,000 | $15,454 |
| Vivo Capital, LLC | 353,998 | $14,588 |
| GREAT POINT PARTNERS LLC | 350,000 | $14,424 |
| Logos Global Management LP | 315,000 | $12,981 |
| Candriam S.C.A. | 311,150 | $12,823 |
| Spruce Street Capital LP | 297,437 | $12,257 |
| Integral Health Asset Management, LLC | 275,000 | $11,333 |
| TANG CAPITAL MANAGEMENT LLC | 264,692 | $10,908 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 250,812 | $10,336 |
| ExodusPoint Capital Management, LP | 246,788 | $10,170 |
| Iron Triangle Partners LP | 230,730 | $9,508 |
| MORGAN STANLEY | 228,016 | $9,397 |
| Woodline Partners LP | 213,087 | $8,781 |
| DIMENSIONAL FUND ADVISORS LP | 210,673 | $8,682 |
| NORTHERN TRUST CORP | 207,246 | $8,541 |
| Squarepoint Ops LLC | 207,119 | $8,535 |
| Walleye Capital LLC | 205,815 | $8,482 |
| Artia Global Partners LP | 205,090 | $8,452 |
| Nuveen, LLC | 190,615 | $7,855 |
| Schonfeld Strategic Advisors LLC | 182,619 | $7,526 |
| Atom Investors LP | 181,860 | $7,494 |
| BARCLAYS PLC | 176,300 | $7,265 |
| AMERIPRISE FINANCIAL INC | 155,163 | $6,394 |
| D. E. Shaw & Co., Inc. | 154,678 | $6,374 |
| Patient Square Capital LP | 150,000 | $6,182 |
| Atika Capital Management LLC | 134,528 | $5,544 |
| Ensign Peak Advisors, Inc | 134,416 | $5,539 |
| ALGERT GLOBAL LLC | 130,326 | $5 |
| Affinity Asset Advisors, LLC | 115,000 | $4,739 |
| Invesco Ltd. | 101,489 | $4,182 |
| PFM Health Sciences, LP | 99,576 | $4,104 |
| Rhenman & Partners Asset Management AB | 98,627 | $4,064 |
| Russell Investments Group, Ltd. | 88,289 | $3,638 |
| SummitTX Capital, L.P. | 87,926 | $3,623 |
| NEUBERGER BERMAN GROUP LLC | 87,782 | $3,617 |
| EAM Investors, LLC | 84,636 | $3,488 |
| STEMPOINT CAPITAL LP | 79,284 | $3,267 |
| Bank of New York Mellon Corp | 75,132 | $3,096 |
| AMERICAN CENTURY COMPANIES INC | 72,767 | $2,999 |
| Rafferty Asset Management, LLC | 57,875 | $2,385 |
| Brevan Howard Capital Management LP | 51,700 | $2,137 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,466 | $2,121 |
| HighVista Strategies LLC | 48,484 | $1,998 |
| Public Sector Pension Investment Board | 48,477 | $1,998 |
| TWO SIGMA INVESTMENTS, LP | 48,400 | $1,995 |
| Cinctive Capital Management LP | 45,906 | $1,892 |
| JANE STREET GROUP, LLC | 45,833 | $1,889 |
| JPMORGAN CHASE & CO | 42,639 | $1,757 |
| Moody Aldrich Partners LLC | 41,304 | $1,702 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 39,480 | $1,627 |
| PNC Financial Services Group, Inc. | 37,221 | $1,534 |
| ALPS ADVISORS INC | 35,206 | $1,451 |
| FRED ALGER MANAGEMENT, LLC | 33,460 | $1,379 |
| RENAISSANCE TECHNOLOGIES LLC | 32,100 | $1,323 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,039 | $1,319 |
| TD Asset Management Inc | 31,750 | $1,308 |
| Swiss National Bank | 31,400 | $1,294 |
| RHUMBLINE ADVISERS | 31,029 | $1,279 |
| WELLS FARGO & COMPANY/MN | 28,968 | $1,194 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 26,249 | $1,082 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,598 | $1,050 |
| Ishara Investments LP | 24,000 | $989 |
| Jain Global LLC | 23,694 | $976 |
| Engineers Gate Manager LP | 23,380 | $963 |
| TWO SIGMA ADVISERS, LP | 22,000 | $907 |
| PROFUND ADVISORS LLC | 21,340 | $879 |
| ArrowMark Colorado Holdings LLC | 20,788 | $857 |
| Lighthouse Investment Partners, LLC | 20,000 | $824 |
| SG Americas Securities, LLC | 18,565 | $1 |
| 66 other institutions | 461,135 | $17,894 |