DISC MEDICINE INC

Ticker: IRON CUSIP: 254604101 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2024

Shares 14,711 Value ($000) $916 Avg Close $64.84 Range $55.75 - $77.60

Q4 2023

Shares 23,094 Value ($000) $1,334 Avg Close $51.20 Range $41.64 - $66.61

Q3 2023

Shares 9,300 Value ($000) $437 Avg Close $50.02 Range $41.61 - $56.99

Q2 2023

Shares 40,261 Value ($000) $1,788 Avg Close $35.48 Range $20.05 - $57.70

Q1 2023

Shares 24,150 Value ($000) $512 Avg Close $22.28 Range $16.05 - $26.43

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2024	14,711	$916	$64.84	$55.75 - $77.60
Q4 2023	23,094	$1,334	$51.20	$41.64 - $66.61
Q3 2023	9,300	$437	$50.02	$41.61 - $56.99
Q2 2023	40,261	$1,788	$35.48	$20.05 - $57.70
Q1 2023	24,150	$512	$22.28	$16.05 - $26.43