| FMR LLC | 5,450,222 | $432,802 |
| BlackRock, Inc. | 2,274,980 | $180,656 |
| RA CAPITAL MANAGEMENT, L.P. | 1,976,132 | $156,925 |
| VANGUARD GROUP INC | 1,767,680 | $140,371 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,698,005 | $135 |
| JPMORGAN CHASE & CO | 1,581,127 | $125,557 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,518,274 | $120,566 |
| Atlas Venture Life Science Advisors, LLC | 1,513,875 | $120,217 |
| Frazier Life Sciences Management, L.P. | 1,260,000 | $100,057 |
| STATE STREET CORP | 1,187,991 | $94,338 |
| ORBIMED ADVISORS LLC | 1,067,550 | $84,774 |
| Siren, L.L.C. | 988,401 | $78,489 |
| Woodline Partners LP | 957,833 | $76,062 |
| GOLDMAN SACHS GROUP INC | 754,195 | $59,891 |
| Vestal Point Capital, LP | 735,000 | $58,366 |
| GEODE CAPITAL MANAGEMENT, LLC | 684,958 | $54,402 |
| BVF INC/IL | 650,000 | $51,617 |
| JENNISON ASSOCIATES LLC | 532,079 | $42,252 |
| First Light Asset Management, LLC | 523,167 | $41,545 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 511,163 | $40,591 |
| Logos Global Management LP | 510,000 | $40,499 |
| ARMISTICE CAPITAL, LLC | 499,391 | $39,657 |
| Checkpoint Capital L.P. | 452,992 | $35,972 |
| PERCEPTIVE ADVISORS LLC | 450,743 | $35,794 |
| EVENTIDE ASSET MANAGEMENT, LLC | 395,392 | $31,398 |
| Pictet Asset Management Holding SA | 394,374 | $31,317 |
| Assenagon Asset Management S.A. | 357,836 | $28,416 |
| BAKER BROS. ADVISORS LP | 337,050 | $26,765 |
| Palo Alto Investors LP | 317,456 | $25,209 |
| Foresite Capital Management V, LLC | 299,069 | $23,749 |
| Saturn V Capital Management LP | 298,429 | $23,698 |
| LOOMIS SAYLES & CO L P | 282,409 | $22,426 |
| GREAT POINT PARTNERS LLC | 250,000 | $19,853 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 247,039 | $19,617 |
| abrdn plc | 234,358 | $18,610 |
| NORTHERN TRUST CORP | 228,070 | $18,111 |
| DIMENSIONAL FUND ADVISORS LP | 223,575 | $17,747 |
| BALYASNY ASSET MANAGEMENT L.P. | 221,761 | $17,610 |
| Opaleye Management Inc. | 200,000 | $15,882 |
| TimesSquare Capital Management, LLC | 187,777 | $14,911 |
| MILLENNIUM MANAGEMENT LLC | 184,779 | $14,673 |
| Ensign Peak Advisors, Inc | 177,050 | $14,060 |
| First Turn Management, LLC | 153,206 | $12,166 |
| BANK OF AMERICA CORP /DE/ | 135,986 | $10,799 |
| Nantahala Capital Management, LLC | 132,800 | $10,546 |
| BNP PARIBAS ARBITRAGE, SA | 122,153 | $9,700 |
| UBS Group AG | 116,112 | $9,220 |
| UBS ASSET MANAGEMENT AMERICAS INC | 114,351 | $9,081 |
| Sofinnova Investments, Inc. | 111,010 | $8,815 |
| Catalio Capital Management, LP | 110,427 | $8,769 |
| CITADEL ADVISORS LLC | 100,395 | $7,972 |
| BARCLAYS PLC | 99,612 | $7,910 |
| DnB Asset Management AS | 84,255 | $6,691 |
| AMERIPRISE FINANCIAL INC | 82,984 | $6,590 |
| RAYMOND JAMES FINANCIAL INC | 80,274 | $6,182 |
| VICTORY CAPITAL MANAGEMENT INC | 76,338 | $6,062 |
| MORGAN STANLEY | 74,826 | $5,942 |
| Patient Square Capital LP | 74,000 | $5,876 |
| TD Asset Management Inc | 69,634 | $5,530 |
| Bank of New York Mellon Corp | 67,707 | $5,377 |
| iA Global Asset Management Inc. | 66,430 | $5 |
| TUDOR INVESTMENT CORP ET AL | 66,125 | $5,251 |
| Verition Fund Management LLC | 63,535 | $5,045 |
| RENAISSANCE TECHNOLOGIES LLC | 62,820 | $4,989 |
| Invesco Ltd. | 61,070 | $4,850 |
| KVP Capital Advisors, LP | 58,250 | $4,626 |
| ExodusPoint Capital Management, LP | 58,211 | $4,623 |
| LAZARD ASSET MANAGEMENT LLC | 58,053 | $4,610 |
| Sio Capital Management, LLC | 57,586 | $4,573 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52,510 | $4,072 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 50,103 | $3,852 |
| Alyeska Investment Group, L.P. | 50,000 | $3,971 |
| Burkehill Global Management, LP | 50,000 | $3,971 |
| Brevan Howard Capital Management LP | 49,713 | $3,893 |
| Nuveen, LLC | 48,471 | $3,849 |
| Nicholas Investment Partners, LP | 48,082 | $3,818 |
| Swiss National Bank | 48,000 | $3,812 |
| HealthInvest Partners AB | 47,967 | $3,809 |
| Exome Asset Management LLC | 46,743 | $3,712 |
| NEXTBio Capital Management LP | 42,778 | $3,397 |
| BNP Paribas Investment Partners S.A. | 40,203 | $3 |
| CITIGROUP INC | 36,176 | $2,873 |
| Rafferty Asset Management, LLC | 36,093 | $2,866 |
| SEVEN GRAND MANAGERS, LLC | 35,000 | $2,779 |
| WELLS FARGO & COMPANY/MN | 33,265 | $2,642 |
| ALPS ADVISORS INC | 31,002 | $2,462 |
| AMERICAN CENTURY COMPANIES INC | 30,328 | $2,408 |
| RTW INVESTMENTS, LP | 30,000 | $2,382 |
| RHUMBLINE ADVISERS | 29,833 | $2,369 |
| Zimmer Partners, LP | 27,500 | $2,184 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 27,301 | $2,168 |
| Eagle Health Investments LP | 27,100 | $2,152 |
| PNC Financial Services Group, Inc. | 25,200 | $2,001 |
| BANK OF MONTREAL /CAN/ | 24,826 | $1,971 |
| ALLIANCEBERNSTEIN L.P. | 24,540 | $1,949 |
| Russell Investments Group, Ltd. | 23,683 | $1,881 |
| Legal & General Group Plc | 23,653 | $1,878 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,256 | $1,847 |
| XTX Topco Ltd | 23,094 | $1,834 |
| SG Americas Securities, LLC | 21,122 | $2 |
| 94 other institutions | 444,163 | $33,483 |