DURECT CORP

CUSIP: 266605104 Class: COM

Redmile Group, LLC's Holding History (CIK: 0001425738)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 2,327,137 Value ($000) $3,142 Avg Close — Range —
Q4 2015
Shares 2,628,416 Value ($000) $5,809 Avg Close — Range —
Q3 2015
Shares 2,613,316 Value ($000) $5,096 Avg Close — Range —