Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	173,859	$9.821M	0.7%	$58.72	0.0%	COM	09061G101
PRME	PRIME MEDICINE INC	1,590,832	$5.536M	0.4%	$3.80	0.0%	COM	74168J101
EPRX	EUPRAXIA PHARMACEUTICALS INC	700,000	$5.068M	0.3%	$8.37	0.0%	COM	29842P105
ARDX	ARDELYX INC	733,350	$4.393M	0.3%	$7.08	0.0%	COM	039697107
AGMB	AGOMAB THERAPEUTICS NV	156,250	$1.639M	0.1%	$10.49	—	SPONSORED ADS	00860C102

Increased Positions (6)

SRRK SCHOLAR ROCK HLDG CORP 29.5%

Value $446M (+93.8%) Shares 9,066,621 (+73.7%) Est. Cost $29.98 Unrealized +51.7%

ANNX ANNEXON INC 5.3%

Value $80.61M (+59.8%) Shares 14,549,768 (+44.8%) Est. Cost $8.54 Unrealized -32.7%

ALXO ALX ONCOLOGY HLDGS INC 1.1%

Value $15.97M (+332.8%) Shares 7,964,188 (+143.9%) Est. Cost $7.38 Unrealized -76.0%

XENE XENON PHARMACEUTICALS INC 1.0%

Value $15.27M (+154.5%) Shares 262,674 (+96.2%) Est. Cost $41.99 Unrealized -0.0%

STOK STOKE THERAPEUTICS INC 9.0%

Value $136M (+5.9%) Shares 4,164,120 (+3.2%) Est. Cost $9.71 Unrealized +227.8%

SLDB SOLID BIOSCIENCES INC 1.0%

Value $14.49M (+38.0%) Shares 2,011,895 (+8.1%) Est. Cost $4.76 Unrealized +27.2%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
SRRK	SCHOLAR ROCK HLDG CORP	9,066,621 (+73.7%)	$446M (+93.8%)	29.5%	$29.98	+51.7%	COM	80706P103
ANNX	ANNEXON INC	14,549,768 (+44.8%)	$80.61M (+59.8%)	5.3%	$8.54	-32.7%	COM	03589W102
ALXO	ALX ONCOLOGY HLDGS INC	7,964,188 (+143.9%)	$15.97M (+332.8%)	1.1%	$7.38	-76.0%	COM	00166B105
XENE	XENON PHARMACEUTICALS INC	262,674 (+96.2%)	$15.27M (+154.5%)	1.0%	$41.99	-0.0%	COM	98420N105
STOK	STOKE THERAPEUTICS INC	4,164,120 (+3.2%)	$136M (+5.9%)	9.0%	$9.71	+227.8%	COM	86150R107
SLDB	SOLID BIOSCIENCES INC	2,011,895 (+8.1%)	$14.49M (+38.0%)	1.0%	$4.76	+27.2%	COM NEW	83422E204

Exited Positions (4)

RAPT RAPT THERAPEUTICS INC 2.0%

Value $30.01M Shares 885,927 Est. Cost $16.44 Unrealized +207.2%

REPL REPLIMUNE GROUP INC 0.7%

Value $10.69M Shares 1,099,756 Est. Cost $12.40 Unrealized -37.1%

— REPARE THERAPEUTICS INC 0.3%

Value $4.124M Shares 1,586,174 Est. Cost $30.51 Unrealized —

KLRS KALARIS THERAPEUTICS INC 0.0%

Value $700K Shares 82,955 Est. Cost $9.79 Unrealized -4.3%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
RAPT	RAPT THERAPEUTICS INC	885,927	$30.01M	2.0%	$16.44	+207.2%	—	75382E208
REPL	REPLIMUNE GROUP INC	1,099,756	$10.69M	0.7%	$12.40	-37.1%	—	76029N106
—	REPARE THERAPEUTICS INC	1,586,174	$4.124M	0.3%	$30.51	—	—	760273102
KLRS	KALARIS THERAPEUTICS INC	82,955	$700K	0.0%	$9.79	-4.3%	—	482929106

Decreased Positions (14)

NRIX NURIX THERAPEUTICS INC 7.9%

Value $120M (-21.9%) Shares 7,732,808 (-4.5%) Est. Cost $17.18 Unrealized +0.9%

COGT COGENT BIOSCIENCES INC 1.8%

Value $26.48M (-48.1%) Shares 688,036 (-52.2%) Est. Cost $9.95 Unrealized +275.5%

IDYA IDEAYA BIOSCIENCES INC 1.1%

Value $17.36M (-32.3%) Shares 521,117 (-29.8%) Est. Cost $27.49 Unrealized +23.2%

BEAM BEAM THERAPEUTICS INC 2.0%

Value $29.49M (-17.3%) Shares 1,237,659 (-3.7%) Est. Cost $26.47 Unrealized +10.2%

IVVD INVIVYD INC 0.2%

Value $3.443M (-48.0%) Shares 2,648,659 (-1.2%) Est. Cost $16.17 Unrealized -87.8%

ADCT ADC THERAPEUTICS SA 3.8%

Value $58.01M (+4.9%) Shares 15,470,502 (-1.3%) Est. Cost $19.52 Unrealized -80.4%

CBLL CERIBELL INC 0.5%

Value $7.09M (-25.7%) Shares 386,786 (-11.1%) Est. Cost $27.25 Unrealized -22.6%

ESTA ESTABLISHMENT LABS HLDGS INC 0.4%

Value $5.875M (-28.5%) Shares 103,464 (-8.2%) Est. Cost $44.21 Unrealized +59.1%

ORIC ORIC PHARMACEUTICALS INC 0.3%

Value $5.267M (+43.7%) Shares 415,710 (-7.2%) Est. Cost $11.51 Unrealized -6.5%

IMNM IMMUNOME INC 8.1%

Value $122M (-1.0%) Shares 5,558,885 (-2.8%) Est. Cost $11.49 Unrealized +100.8%

PLRX PLIANT THERAPEUTICS INC 0.1%

Value $973K (-50.7%) Shares 772,126 (-52.2%) Est. Cost $22.50 Unrealized -94.5%

CLDX CELLDEX THERAPEUTICS INC NEW 0.5%

Value $8.295M (+7.8%) Shares 261,508 (-7.7%) Est. Cost $11.60 Unrealized +119.2%

LIVN LIVANOVA PLC 0.5%

Value $6.887M (-5.2%) Shares 108,354 (-8.2%) Est. Cost $70.40 Unrealized -7.5%

DBVT DBV TECHNOLOGIES S A 0.7%

Value $10.26M (-2.6%) Shares 491,340 (-10.6%) Est. Cost $19.17 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
NRIX	NURIX THERAPEUTICS INC	7,732,808 (-4.5%)	$120M (-21.9%)	7.9%	$17.18	+0.9%	COM	67080M103
COGT	COGENT BIOSCIENCES INC	688,036 (-52.2%)	$26.48M (-48.1%)	1.8%	$9.95	+275.5%	COM	19240Q201
IDYA	IDEAYA BIOSCIENCES INC	521,117 (-29.8%)	$17.36M (-32.3%)	1.1%	$27.49	+23.2%	COM	45166A102
BEAM	BEAM THERAPEUTICS INC	1,237,659 (-3.7%)	$29.49M (-17.3%)	2.0%	$26.47	+10.2%	COM	07373V105
IVVD	INVIVYD INC	2,648,659 (-1.2%)	$3.443M (-48.0%)	0.2%	$16.17	-87.8%	COM	00534A102
ADCT	ADC THERAPEUTICS SA	15,470,502 (-1.3%)	$58.01M (+4.9%)	3.8%	$19.52	-80.4%	SHS	H0036K147
CBLL	CERIBELL INC	386,786 (-11.1%)	$7.09M (-25.7%)	0.5%	$27.25	-22.6%	COM	15678C102
ESTA	ESTABLISHMENT LABS HLDGS INC	103,464 (-8.2%)	$5.875M (-28.5%)	0.4%	$44.21	+59.1%	COM	G31249108
ORIC	ORIC PHARMACEUTICALS INC	415,710 (-7.2%)	$5.267M (+43.7%)	0.3%	$11.51	-6.5%	COM	68622P109
IMNM	IMMUNOME INC	5,558,885 (-2.8%)	$122M (-1.0%)	8.1%	$11.49	+100.8%	COM	45257U108
PLRX	PLIANT THERAPEUTICS INC	772,126 (-52.2%)	$973K (-50.7%)	0.1%	$22.50	-94.5%	COM	729139105
CLDX	CELLDEX THERAPEUTICS INC NEW	261,508 (-7.7%)	$8.295M (+7.8%)	0.5%	$11.60	+119.2%	COM NEW	15117B202
LIVN	LIVANOVA PLC	108,354 (-8.2%)	$6.887M (-5.2%)	0.5%	$70.40	-7.5%	SHS	G5509L101
DBVT	DBV TECHNOLOGIES S A	491,340 (-10.6%)	$10.26M (-2.6%)	0.7%	$19.17	—	SPONSORED ADS	23306J309

Unchanged Positions (10)

RGNX REGENXBIO INC 2.4%

Value $36.61M Shares 4,368,804 Est. Cost $22.74 Unrealized -49.0%

STTK SHATTUCK LABS INC 2.4%

Value $35.62M Shares 5,539,724 Est. Cost $32.14 Unrealized -87.1%

NUVB NUVATION BIO INC 0.9%

Value $13.53M Shares 3,153,256 Est. Cost $10.97 Unrealized -43.6%

KRYS KRYSTAL BIOTECH INC 11.5%

Value $174M Shares 673,505 Est. Cost $62.38 Unrealized +336.7%

ATRA ATARA BIOTHERAPEUTICS INC 0.1%

Value $2.089M Shares 441,701 Est. Cost $15.04 Unrealized -56.2%

ABSI ABSCI CORPORATION 1.6%

Value $24.76M Shares 8,253,316 Est. Cost $19.01 Unrealized -84.2%

FATE FATE THERAPEUTICS INC 1.0%

Value $15.45M Shares 12,872,946 Est. Cost $13.12 Unrealized -90.8%

SLN SILENCE THERAPEUTICS PLC 0.8%

Value $11.41M Shares 2,164,777 Est. Cost $18.53 Unrealized —

NGNE NEUROGENE INC 1.9%

Value $29.43M Shares 1,459,599 Est. Cost $22.00 Unrealized -17.5%

ZYME ZYMEWORKS INC 0.8%

Value $12.31M Shares 491,654 Est. Cost $7.05 Unrealized +231.7%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
RGNX	REGENXBIO INC	4,368,804	$36.61M	2.4%	$22.74	-49.0%	COM	75901B107
STTK	SHATTUCK LABS INC	5,539,724	$35.62M	2.4%	$32.14	-87.1%	COM	82024L103
NUVB	NUVATION BIO INC	3,153,256	$13.53M	0.9%	$10.97	-43.6%	COM CL A	67080N101
KRYS	KRYSTAL BIOTECH INC	673,505	$174M	11.5%	$62.38	+336.7%	COM	501147102
ATRA	ATARA BIOTHERAPEUTICS INC	441,701	$2.089M	0.1%	$15.04	-56.2%	COM NEW	046513206
ABSI	ABSCI CORPORATION	8,253,316	$24.76M	1.6%	$19.01	-84.2%	COM	00091E109
FATE	FATE THERAPEUTICS INC	12,872,946	$15.45M	1.0%	$13.12	-90.8%	COM	31189P102
SLN	SILENCE THERAPEUTICS PLC	2,164,777	$11.41M	0.8%	$18.53	—	ADS	82686Q101
NGNE	NEUROGENE INC	1,459,599	$29.43M	1.9%	$22.00	-17.5%	COM	64135M105
ZYME	ZYMEWORKS INC	491,654	$12.31M	0.8%	$7.05	+231.7%	COM	98985Y108