DYNE THERAPEUTICS INC

Ticker: DYN CUSIP: 26818M108 Class: Common Stock

Palo Alto Investors LP's Holding History (CIK: 0001306923)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,472,197 Value ($000) $28,796 Avg Close $18.94 Range $12.33 - $25.00

Q3 2025

Shares 1,262,674 Value ($000) $15,973 Avg Close $11.41 Range $8.06 - $14.35

Q2 2025

Shares 264,976 Value ($000) $2,523 Avg Close $11.01 Range $6.36 - $15.23

Q1 2025

Shares 333,391 Value ($000) $3,487 Avg Close $14.30 Range $9.96 - $26.22

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,472,197	$28,796	$18.94	$12.33 - $25.00
Q3 2025	1,262,674	$15,973	$11.41	$8.06 - $14.35
Q2 2025	264,976	$2,523	$11.01	$6.36 - $15.23
Q1 2025	333,391	$3,487	$14.30	$9.96 - $26.22