| JANUS HENDERSON GROUP PLC | 13,887,722 | $271,604 |
| VANGUARD GROUP INC | 11,215,565 | $219,376 |
| BlackRock, Inc. | 11,190,838 | $218,893 |
| Atlas Venture Life Science Advisors, LLC | 9,130,465 | $178,592 |
| STATE STREET CORP | 6,692,745 | $130,910 |
| FMR LLC | 6,569,921 | $128,508 |
| FCPM III SERVICES B.V. | 5,462,846 | $106,853 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,172,000 | $101,164 |
| Orbis Allan Gray Ltd | 4,801,928 | $93,926 |
| TCG Crossover Management, LLC | 4,615,144 | $90,272 |
| JPMORGAN CHASE & CO | 3,549,909 | $69,436 |
| Siren, L.L.C. | 3,502,941 | $68,518 |
| PERCEPTIVE ADVISORS LLC | 3,478,944 | $68,048 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,263,429 | $63,844 |
| ARMISTICE CAPITAL, LLC | 3,249,708 | $63,564 |
| Frazier Life Sciences Management, L.P. | 3,153,082 | $61,674 |
| T. Rowe Price Investment Management, Inc. | 2,870,568 | $56 |
| Deep Track Capital, LP | 2,650,000 | $51,834 |
| Vivo Capital, LLC | 2,614,960 | $51,149 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,323,789 | $45 |
| GOLDMAN SACHS GROUP INC | 2,283,191 | $44,659 |
| Sofinnova Investments, Inc. | 2,254,161 | $44,091 |
| ORBIMED ADVISORS LLC | 2,202,184 | $43,075 |
| VR Adviser, LLC | 2,173,913 | $42,522 |
| FRANKLIN RESOURCES INC | 2,006,638 | $39,250 |
| Saturn V Capital Management LP | 1,788,616 | $34,985 |
| SAMLYN CAPITAL, LLC | 1,493,075 | $29,205 |
| BRAIDWELL LP | 1,478,329 | $28,916 |
| Palo Alto Investors LP | 1,472,197 | $28,796 |
| MPM BioImpact LLC | 1,405,388 | $27,489 |
| Polar Capital Holdings Plc | 1,269,131 | $24,824 |
| Logos Global Management LP | 1,250,000 | $24,450 |
| MORGAN STANLEY | 1,213,559 | $23,737 |
| CITADEL ADVISORS LLC | 1,171,624 | $22,917 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,151,325 | $22,520 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,138,868 | $22,276 |
| abrdn plc | 1,108,145 | $21,675 |
| NORTHERN TRUST CORP | 1,092,191 | $21,363 |
| Candriam S.C.A. | 1,057,263 | $20,681 |
| Rock Springs Capital Management LP | 912,955 | $17,857 |
| MILLENNIUM MANAGEMENT LLC | 904,389 | $17,690 |
| BANK OF AMERICA CORP /DE/ | 882,922 | $17,270 |
| STEMPOINT CAPITAL LP | 835,200 | $16,337 |
| BAKER BROS. ADVISORS LP | 813,449 | $15,911 |
| ArrowMark Colorado Holdings LLC | 700,653 | $13,705 |
| EVENTIDE ASSET MANAGEMENT, LLC | 680,305 | $13,306 |
| MARSHALL WACE, LLP | 676,979 | $13,242 |
| Artisan Partners Limited Partnership | 649,691 | $12,708 |
| Nuveen, LLC | 621,310 | $12,153 |
| RAYMOND JAMES FINANCIAL INC | 530,338 | $10,373 |
| Catalio Capital Management, LP | 519,715 | $10,166 |
| Ensign Peak Advisors, Inc | 496,590 | $9,713 |
| RENAISSANCE TECHNOLOGIES LLC | 470,645 | $9,206 |
| FEDERATED HERMES, INC. | 464,797 | $9,091 |
| BARCLAYS PLC | 448,658 | $8,776 |
| BALYASNY ASSET MANAGEMENT L.P. | 432,986 | $8,469 |
| TD Asset Management Inc | 419,756 | $8,210 |
| University of Wisconsin Foundation | 416,750 | $8,152 |
| Qube Research & Technologies Ltd | 412,440 | $8,067 |
| Clearbridge Investments, LLC | 407,794 | $7,976 |
| WASATCH ADVISORS LP | 406,960 | $7,960 |
| SPHERA FUNDS MANAGEMENT LTD. | 392,894 | $7,685 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 386,953 | $7,429 |
| UBS Group AG | 380,978 | $7,452 |
| Bank of New York Mellon Corp | 353,497 | $6,914 |
| Y-Intercept (Hong Kong) Ltd | 343,726 | $6,723 |
| Point72 Asset Management, L.P. | 329,345 | $6,442 |
| CANADA PENSION PLAN INVESTMENT BOARD | 284,000 | $5,555 |
| ALGERT GLOBAL LLC | 271,303 | $5 |
| SG Americas Securities, LLC | 265,384 | $5 |
| Squarepoint Ops LLC | 255,160 | $4,991 |
| Fisher Asset Management, LLC | 250,065 | $4,891 |
| Tetragon Partners GP Ltd | 247,997 | $4,851 |
| SummitTX Capital, L.P. | 243,276 | $4,758 |
| Neo Ivy Capital Management | 237,467 | $4,645 |
| Rafferty Asset Management, LLC | 233,835 | $4,574 |
| Russell Investments Group, Ltd. | 232,013 | $4,538 |
| Swiss National Bank | 222,500 | $4,352 |
| UBS ASSET MANAGEMENT AMERICAS INC | 214,491 | $4,195 |
| AMERIPRISE FINANCIAL INC | 197,691 | $3,867 |
| DEUTSCHE BANK AG\ | 196,080 | $3,835 |
| PDT Partners, LLC | 182,986 | $3,579 |
| RHUMBLINE ADVISERS | 175,020 | $3,423 |
| AMERICAN CENTURY COMPANIES INC | 168,304 | $3,292 |
| BNP Paribas Investment Partners S.A. | 165,692 | $3 |
| NEUBERGER BERMAN GROUP LLC | 165,482 | $3,237 |
| Jain Global LLC | 162,047 | $3,170 |
| Brevan Howard Capital Management LP | 157,969 | $3,090 |
| First Light Asset Management, LLC | 155,231 | $3,036 |
| Burkehill Global Management, LP | 155,000 | $3,032 |
| Lisanti Capital Growth, LLC | 154,445 | $3,021 |
| WELLS FARGO & COMPANY/MN | 147,831 | $2,892 |
| TUDOR INVESTMENT CORP ET AL | 147,621 | $2,887 |
| Invesco Ltd. | 137,684 | $2,693 |
| ALLIANCEBERNSTEIN L.P. | 134,260 | $2,626 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 120,800 | $2,363 |
| Woodline Partners LP | 120,788 | $2,363 |
| Vestal Point Capital, LP | 120,000 | $2,347 |
| Legal & General Group Plc | 118,122 | $2,310 |
| Darwin Wealth Management, LLC | 115,267 | $2,255 |
| 129 other institutions | 3,366,895 | $62,030 |