EDGEWISE THERAPEUTICS INC

Ticker: EWTX CUSIP: 28036F105 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 50,848 Value ($000) $1,262 Avg Close $20.07 Range $14.25 - $27.39

Q3 2025

Shares 26,266 Value ($000) $426 Avg Close $14.18 Range $12.30 - $17.00

Q1 2025

Shares 34,999 Value ($000) $770 Avg Close $26.23 Range $21.52 - $30.48

Q4 2024

Shares 131,667 Value ($000) $3,516 Avg Close $31.84 Range $25.97 - $38.12

Q3 2024

Shares 261,458 Value ($000) $6,978 Avg Close $19.89 Range $15.02 - $30.00

Q2 2024

Shares 362,576 Value ($000) $6,530 Avg Close $17.44 Range $14.90 - $21.60

Q1 2024

Shares 392,735 Value ($000) $7,163 Avg Close $15.89 Range $9.00 - $20.69

Q4 2023

Shares 169,542 Value ($000) $1,855 Avg Close $7.02 Range $5.12 - $12.46

Q3 2023

Shares 57,564 Value ($000) $330 Avg Close $6.80 Range $5.49 - $7.92

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	50,848	$1,262	$20.07	$14.25 - $27.39
Q3 2025	26,266	$426	$14.18	$12.30 - $17.00
Q1 2025	34,999	$770	$26.23	$21.52 - $30.48
Q4 2024	131,667	$3,516	$31.84	$25.97 - $38.12
Q3 2024	261,458	$6,978	$19.89	$15.02 - $30.00
Q2 2024	362,576	$6,530	$17.44	$14.90 - $21.60
Q1 2024	392,735	$7,163	$15.89	$9.00 - $20.69
Q4 2023	169,542	$1,855	$7.02	$5.12 - $12.46
Q3 2023	57,564	$330	$6.80	$5.49 - $7.92