| ORBIMED ADVISORS LLC | 15,518,492 | $385,091 |
| RA CAPITAL MANAGEMENT, L.P. | 10,428,437 | $258,782 |
| BlackRock, Inc. | 6,630,576 | $164,538 |
| BAKER BROS. ADVISORS LP | 6,575,940 | $163,182 |
| Paradigm Biocapital Advisors LP | 6,541,210 | $162,320 |
| Novo Holdings A/S | 5,350,000 | $132,760 |
| BRAIDWELL LP | 5,210,831 | $129,307 |
| VANGUARD GROUP INC | 4,871,624 | $120,889 |
| JANUS HENDERSON GROUP PLC | 4,566,850 | $113,326 |
| Siren, L.L.C. | 4,529,990 | $112,412 |
| PERCEPTIVE ADVISORS LLC | 4,457,974 | $110,625 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,191,193 | $104,004 |
| Cormorant Asset Management, LP | 3,285,000 | $81,517 |
| MORGAN STANLEY | 2,910,881 | $72,234 |
| UBS Group AG | 2,117,073 | $52,535 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,746,222 | $43,340 |
| STATE STREET CORP | 1,717,343 | $42,616 |
| MPM BioImpact LLC | 1,655,256 | $41,075 |
| First Light Asset Management, LLC | 1,573,701 | $39,051 |
| Bellevue Group AG | 1,528,518 | $37,930 |
| Integral Health Asset Management, LLC | 1,500,000 | $37,223 |
| BANK OF AMERICA CORP /DE/ | 1,474,797 | $36,597 |
| DIMENSIONAL FUND ADVISORS LP | 1,213,657 | $30,115 |
| AMERICAN CENTURY COMPANIES INC | 1,186,467 | $29,442 |
| ALLIANCEBERNSTEIN L.P. | 1,036,170 | $25,713 |
| Soleus Capital Management, L.P. | 910,000 | $22,582 |
| abrdn plc | 821,940 | $20,396 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 765,694 | $19,001 |
| NORGES BANK | 751,355 | $18,645 |
| VICTORY CAPITAL MANAGEMENT INC | 746,562 | $18,526 |
| GOLDMAN SACHS GROUP INC | 718,372 | $17,826 |
| Artisan Partners Limited Partnership | 704,077 | $17,472 |
| FMR LLC | 692,955 | $17,196 |
| MARSHALL WACE, LLP | 681,921 | $16,925 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 640,400 | $15,892 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 611,384 | $15,171 |
| EVENTIDE ASSET MANAGEMENT, LLC | 568,310 | $14,103 |
| NORTHERN TRUST CORP | 559,649 | $13,888 |
| Candriam S.C.A. | 501,214 | $12,438 |
| Opaleye Management Inc. | 500,000 | $12,408 |
| Sofinnova Investments, Inc. | 437,819 | $10,864 |
| Parkman Healthcare Partners LLC | 427,690 | $10,613 |
| D. E. Shaw & Co., Inc. | 394,695 | $9,794 |
| BARCLAYS PLC | 372,738 | $9,249 |
| STEMPOINT CAPITAL LP | 360,876 | $8,955 |
| Squadron Capital Management LLC | 350,000 | $8,685 |
| Eversept Partners, LP | 337,340 | $8,371 |
| Qube Research & Technologies Ltd | 296,208 | $7,350 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 271,385 | $6,734 |
| KENNEDY CAPITAL MANAGEMENT LLC | 241,509 | $5,993 |
| Sio Capital Management, LLC | 237,481 | $5,893 |
| Granahan Investment Management, LLC | 232,295 | $5,764 |
| Woodline Partners LP | 224,192 | $5,563 |
| CITIGROUP INC | 223,294 | $5,541 |
| DEUTSCHE BANK AG\ | 214,769 | $5,331 |
| AMERIPRISE FINANCIAL INC | 202,297 | $5,020 |
| Bank of New York Mellon Corp | 198,614 | $4,929 |
| Ally Bridge Group (NY) LLC | 195,000 | $4,839 |
| HighVista Strategies LLC | 171,137 | $4,247 |
| Nuveen, LLC | 169,466 | $4,205 |
| DAFNA Capital Management LLC | 159,736 | $3,964 |
| BALYASNY ASSET MANAGEMENT L.P. | 151,905 | $3,770 |
| JPMORGAN CHASE & CO | 146,038 | $3,624 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 145,286 | $3,565 |
| KVP Capital Advisors, LP | 133,000 | $3,300 |
| NEUBERGER BERMAN GROUP LLC | 127,136 | $3,155 |
| MILLENNIUM MANAGEMENT LLC | 126,436 | $3,138 |
| CITADEL ADVISORS LLC | 123,097 | $3,055 |
| Jain Global LLC | 113,856 | $2,825 |
| WELLINGTON MANAGEMENT GROUP LLP | 111,387 | $2,764 |
| Quantum Private Wealth, LLC | 106,024 | $2,631 |
| Swiss National Bank | 103,900 | $2,578 |
| Exome Asset Management LLC | 100,046 | $2,483 |
| UBS ASSET MANAGEMENT AMERICAS INC | 98,063 | $2,433 |
| ADAR1 Capital Management, LLC | 90,999 | $2,258 |
| NEW YORK STATE COMMON RETIREMENT FUND | 88,937 | $2,207 |
| SG Americas Securities, LLC | 88,723 | $2 |
| ALPS ADVISORS INC | 86,929 | $2,157 |
| RHUMBLINE ADVISERS | 85,075 | $2,111 |
| FEDERATED HERMES, INC. | 82,096 | $2,037 |
| DekaBank Deutsche Girozentrale | 80,000 | $2 |
| Jump Financial, LLC | 79,915 | $1,983 |
| WELLS FARGO & COMPANY/MN | 75,442 | $1,872 |
| Invesco Ltd. | 75,438 | $1,872 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,196 | $1,742 |
| Schonfeld Strategic Advisors LLC | 59,326 | $1,472 |
| Ishara Investments LP | 58,000 | $1,439 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 57,315 | $1 |
| XTX Topco Ltd | 55,620 | $1,380 |
| HighMark Wealth Management LLC | 53,179 | $1,320 |
| Legal & General Group Plc | 52,747 | $1,309 |
| TWO SIGMA INVESTMENTS, LP | 50,848 | $1,262 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 50,392 | $1,250 |
| FRANKLIN RESOURCES INC | 43,145 | $1,071 |
| Moody Aldrich Partners LLC | 43,134 | $1,070 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 42,052 | $1,044 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 41,584 | $1,032 |
| STATE OF WISCONSIN INVESTMENT BOARD | 39,997 | $993 |
| Voya Investment Management LLC | 39,648 | $984 |
| Knights of Columbus Asset Advisors LLC | 38,676 | $960 |
| 97 other institutions | 895,518 | $20,760 |