EPIRUS BIOPHARMACEUTICALS IN

CUSIP: 29428P107 Class: COM

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q1 2015
Shares 15,056 Value ($000) $135 Avg Close — Range —
Q4 2014
Shares 35,936 Value ($000) $204 Avg Close — Range —