EPIZYME INC

CUSIP: 29428V104 Class: COM

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 749,502 Value ($000) $4,617 Avg Close — Range —
Q3 2018
Shares 399,502 Value ($000) $4,235 Avg Close — Range —
Q2 2018
Shares 307,154 Value ($000) $4,162 Avg Close — Range —
Q3 2015
Shares 150,000 Value ($000) $1,929 Avg Close — Range —
Q1 2015
Shares 150,000 Value ($000) $2,817 Avg Close — Range —
Q3 2014
Shares 50,000 Value ($000) $1,356 Avg Close — Range —
Q2 2014
Shares 113,188 Value ($000) $3,522 Avg Close — Range —