| Beutel, Goodman & Co Ltd. | 3,709,373 | $28 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,350,000 | $10,193 |
| Vivo Capital, LLC | 1,350,000 | $10,193 |
| SCOTIA CAPITAL INC. | 1,286,183 | $9,605 |
| GREAT POINT PARTNERS LLC | 1,200,000 | $9,060 |
| Point72 Asset Management, L.P. | 712,104 | $5,376 |
| Ikarian Capital, LLC | 610,000 | $4,606 |
| Squadron Capital Management LLC | 500,000 | $3,775 |
| Ally Bridge Group (NY) LLC | 397,895 | $3,004 |
| Velan Capital Investment Management LP | 352,000 | $2,658 |
| Affinity Asset Advisors, LLC | 300,000 | $2,265 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 278,064 | $2,091 |
| BANK OF AMERICA CORP /DE/ | 253,321 | $1,913 |
| UBS Group AG | 220,024 | $1,661 |
| ROYAL BANK OF CANADA | 196,277 | $1,482 |
| SummitTX Capital, L.P. | 175,948 | $1,328 |
| MARSHALL WACE, LLP | 158,133 | $1,194 |
| BOOTHBAY FUND MANAGEMENT, LLC | 156,331 | $1,180 |
| ACADIAN ASSET MANAGEMENT LLC | 155,766 | $1 |
| INGALLS & SNYDER LLC | 77,400 | $1 |
| GOLDMAN SACHS GROUP INC | 58,058 | $438 |
| CIBC WORLD MARKET INC. | 58,050 | $437 |
| RAYMOND JAMES FINANCIAL INC | 52,972 | $400 |
| Quadrature Capital Ltd | 43,186 | $326 |
| BANK OF MONTREAL /CAN/ | 37,250 | $280 |
| 1832 Asset Management L.P. | 32,138 | $243 |
| JANE STREET GROUP, LLC | 29,622 | $223 |
| XTX Topco Ltd | 16,180 | $122 |
| GEODE CAPITAL MANAGEMENT, LLC | 13,899 | $105 |
| TCI Wealth Advisors, Inc. | 11,000 | $83 |
| Aptus Capital Advisors, LLC | 10,000 | $76 |
| GUARDIAN WEALTH ADVISORS, LLC / NC | 10,000 | $76 |
| TD Waterhouse Canada Inc. | 9,600 | $72 |
| Federation des caisses Desjardins du Quebec | 9,091 | $68 |
| NATIONAL BANK OF CANADA /FI/ | 586 | $4 |