| EQT Fund Management S.a r.l. | 4,929,633 | $84,395 |
| RA CAPITAL MANAGEMENT, L.P. | 3,458,770 | $59,214 |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,926,943 | $32,989 |
| Andera Partners | 1,897,362 | $32,483 |
| Nan Fung Group Holdings Ltd | 1,441,032 | $24,670 |
| JPMORGAN CHASE & CO | 1,308,901 | $22,408 |
| RTW INVESTMENTS, LP | 1,283,671 | $21,976 |
| SymBiosis Capital Partners, LLC | 1,280,778 | $21,927 |
| MARSHALL WACE, LLP | 988,200 | $16,918 |
| EVENTIDE ASSET MANAGEMENT, LLC | 961,525 | $16,461 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 782,121 | $13 |
| SECTORAL ASSET MANAGEMENT INC | 589,005 | $10,084 |
| Verition Fund Management LLC | 565,214 | $9,676 |
| abrdn plc | 525,376 | $8,994 |
| Velan Capital Investment Management LP | 506,754 | $8,676 |
| VANGUARD GROUP INC | 502,574 | $8,604 |
| Octagon Capital Advisors LP | 500,000 | $8,560 |
| AMERICAN CENTURY COMPANIES INC | 417,455 | $7,147 |
| FEDERATED HERMES, INC. | 325,000 | $5,564 |
| GREAT POINT PARTNERS LLC | 325,000 | $5,564 |
| NEXTBio Capital Management LP | 228,286 | $3,908 |
| Defilade Capital Management, L.P. | 215,418 | $3,688 |
| Kynam Capital Management, LP | 185,482 | $3,175 |
| ADAR1 Capital Management, LLC | 184,062 | $3,151 |
| Monashee Investment Management LLC | 183,239 | $3,137 |
| SPHERA FUNDS MANAGEMENT LTD. | 166,147 | $2,844 |
| Sofinnova Investments, Inc. | 153,320 | $2,625 |
| BlackRock, Inc. | 142,440 | $2,439 |
| Integral Health Asset Management, LLC | 125,000 | $2,140 |
| MPM BioImpact LLC | 113,022 | $1,935 |
| GEODE CAPITAL MANAGEMENT, LLC | 109,781 | $1,881 |
| AMERIPRISE FINANCIAL INC | 104,555 | $1,790 |
| SEVEN GRAND MANAGERS, LLC | 75,000 | $1,284 |
| STEMPOINT CAPITAL LP | 68,196 | $1,168 |
| BALYASNY ASSET MANAGEMENT L.P. | 65,000 | $1,113 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 62,704 | $1,073 |
| GOLDMAN SACHS GROUP INC | 61,675 | $1,056 |
| Capricorn Fund Managers Ltd | 60,000 | $1,027 |
| CITADEL ADVISORS LLC | 50,560 | $866 |
| Burkehill Global Management, LP | 50,000 | $856 |
| TD Asset Management Inc | 44,634 | $764 |
| Point72 Asset Management, L.P. | 34,384 | $589 |
| TUDOR INVESTMENT CORP ET AL | 31,953 | $547 |
| STATE STREET CORP | 31,500 | $539 |
| Qube Research & Technologies Ltd | 24,057 | $412 |
| NORTHERN TRUST CORP | 22,636 | $388 |
| TWO SIGMA INVESTMENTS, LP | 21,324 | $365 |
| OXFORD ASSET MANAGEMENT LLP | 19,565 | $335 |
| XTX Topco Ltd | 18,778 | $321 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,225 | $179 |
| MORGAN STANLEY | 8,346 | $143 |
| UBS Group AG | 3,414 | $58 |
| BANK OF AMERICA CORP /DE/ | 2,937 | $50 |
| Tower Research Capital LLC (TRC) | 2,745 | $47 |
| NATIONAL BANK OF CANADA /FI/ | 2,200 | $38 |
| China Universal Asset Management Co., Ltd. | 2,000 | $34 |
| ROYAL BANK OF CANADA | 585 | $10 |
| Legal & General Group Plc | 400 | $7 |
| COMERICA BANK | 20 | $0 |