EXELIXIS INC

Ticker: EXEL CUSIP: 30161Q104 Class: EQTY

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015

Shares 450,000 Value ($000) $2,538 Avg Close $5.60 Range $4.70 - $6.42

Q3 2015

Shares 500,000 Value ($000) $2,805 Avg Close $5.44 Range $3.31 - $6.81

Q2 2015

Shares 400,000 Value ($000) $1,504 Avg Close $3.25 Range $2.51 - $4.18

Q1 2015

Shares 500,000 Value ($000) $1,285 Avg Close $2.32 Range $1.46 - $3.16

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2015	450,000	$2,538	$5.60	$4.70 - $6.42
Q3 2015	500,000	$2,805	$5.44	$3.31 - $6.81
Q2 2015	400,000	$1,504	$3.25	$2.51 - $4.18
Q1 2015	500,000	$1,285	$2.32	$1.46 - $3.16