| Cormorant Asset Management, LP | 8,265,000 | $151,002 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,827,685 | $143,012 |
| BlackRock, Inc. | 6,787,872 | $124,014 |
| FEDERATED HERMES, INC. | 6,017,433 | $109,939 |
| FRANKLIN RESOURCES INC | 4,976,915 | $90,928 |
| VANGUARD GROUP INC | 4,822,139 | $88,100 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,700,000 | $85,869 |
| Paradigm Biocapital Advisors LP | 3,691,475 | $67,443 |
| TCG Crossover Management, LLC | 3,572,335 | $65,267 |
| JANUS HENDERSON GROUP PLC | 2,937,729 | $53,658 |
| ORBIMED ADVISORS LLC | 2,468,314 | $45,096 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,899,367 | $34,710 |
| STATE STREET CORP | 1,834,850 | $33,523 |
| abrdn plc | 1,605,984 | $29,341 |
| GOLDMAN SACHS GROUP INC | 1,249,757 | $22,833 |
| Parkman Healthcare Partners LLC | 1,088,033 | $19,878 |
| Essex Woodlands Management, Inc. | 1,084,857 | $19,820 |
| 5AM Venture Management, LLC | 1,050,000 | $19,184 |
| Spruce Street Capital LP | 981,543 | $17,933 |
| Alyeska Investment Group, L.P. | 784,403 | $14,331 |
| Patient Square Capital LP | 780,000 | $14,251 |
| Artia Global Partners LP | 767,098 | $14,015 |
| Rosalind Advisors, Inc. | 690,000 | $12,606 |
| Candriam S.C.A. | 674,395 | $12,322 |
| Schonfeld Strategic Advisors LLC | 661,452 | $12,085 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 648,565 | $11,849 |
| BALYASNY ASSET MANAGEMENT L.P. | 595,392 | $10,878 |
| NORTHERN TRUST CORP | 577,586 | $10,552 |
| MILLENNIUM MANAGEMENT LLC | 556,469 | $10,167 |
| ExodusPoint Capital Management, LP | 544,077 | $9,940 |
| Principia Wealth Advisory, LLC | 530,725 | $9,696 |
| BANK OF AMERICA CORP /DE/ | 416,100 | $7,602 |
| DIMENSIONAL FUND ADVISORS LP | 402,063 | $7,344 |
| Blue Owl Capital Holdings LP | 392,594 | $7,173 |
| Simplify Asset Management Inc. | 375,264 | $6,856 |
| Granahan Investment Management, LLC | 366,675 | $6,699 |
| STEMPOINT CAPITAL LP | 353,849 | $6,465 |
| Invesco Ltd. | 339,004 | $6,194 |
| Bleichroeder LP | 316,515 | $5,783 |
| MYDA Advisors LLC | 300,000 | $5,481 |
| Rock Springs Capital Management LP | 258,739 | $4,727 |
| Bank of New York Mellon Corp | 256,743 | $4,691 |
| BNP Paribas Investment Partners S.A. | 246,279 | $5 |
| DEUTSCHE BANK AG\ | 226,770 | $4,143 |
| MORGAN STANLEY | 223,699 | $4,087 |
| AMERIPRISE FINANCIAL INC | 213,301 | $3,897 |
| Integral Health Asset Management, LLC | 200,000 | $3,654 |
| UBS Group AG | 188,651 | $3,447 |
| WELLINGTON MANAGEMENT GROUP LLP | 188,199 | $3,438 |
| Nuveen, LLC | 181,256 | $3,312 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 168,382 | $3,012 |
| BARCLAYS PLC | 140,726 | $2,571 |
| TWO SIGMA INVESTMENTS, LP | 138,461 | $2,530 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 137,555 | $2,513 |
| PANAGORA ASSET MANAGEMENT INC | 132,214 | $2,416 |
| Corient Private Wealth LLC | 127,489 | $2,329 |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 124,956 | $2,283 |
| Burkehill Global Management, LP | 115,000 | $2,101 |
| Woodline Partners LP | 100,463 | $1,835 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 92,570 | $2 |
| RHUMBLINE ADVISERS | 89,045 | $1,627 |
| WELLS FARGO & COMPANY/MN | 88,286 | $1,613 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 87,245 | $1,594 |
| Waverly Advisors, LLC | 78,063 | $1,426 |
| ALLIANCEBERNSTEIN L.P. | 75,090 | $1,372 |
| Centiva Capital, LP | 75,000 | $1,370 |
| Susquehanna Portfolio Strategies, LLC | 74,944 | $1,369 |
| WOODSTOCK CORP | 68,465 | $1,251 |
| RENAISSANCE TECHNOLOGIES LLC | 61,600 | $1,125 |
| STATE OF WISCONSIN INVESTMENT BOARD | 60,317 | $1,102 |
| Erste Asset Management GmbH | 50,000 | $910 |
| Voya Investment Management LLC | 47,941 | $876 |
| Marex Group plc | 47,777 | $873 |
| CITIGROUP INC | 45,480 | $831 |
| BNP PARIBAS ARBITRAGE, SA | 43,086 | $787 |
| NISA INVESTMENT ADVISORS, LLC | 42,655 | $779 |
| MetLife Investment Management, LLC | 41,799 | $764 |
| JPMORGAN CHASE & CO | 37,189 | $679 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,106 | $641 |
| DekaBank Deutsche Girozentrale | 35,000 | $1 |
| SIMPLEX TRADING, LLC | 34,525 | $631 |
| SBI Okasan Asset Management Co.Ltd. | 33,600 | $612 |
| HighTower Advisors, LLC | 32,562 | $595 |
| Brevan Howard Capital Management LP | 32,333 | $591 |
| SCOTIA CAPITAL INC. | 31,589 | $577 |
| Creative Planning | 31,218 | $570 |
| Longaeva Partners L.P. | 30,000 | $548 |
| PSP Research LLC | 29,530 | $540 |
| China Universal Asset Management Co., Ltd. | 29,490 | $539 |
| SEI INVESTMENTS CO | 28,820 | $527 |
| Janney Montgomery Scott LLC | 26,415 | $0 |
| OSAIC HOLDINGS, INC. | 25,913 | $473 |
| Cyndeo Wealth Partners, LLC | 22,990 | $420 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,775 | $416 |
| INTECH INVESTMENT MANAGEMENT LLC | 22,201 | $406 |
| AlphaQuest LLC | 20,678 | $378 |
| Police & Firemen's Retirement System of New Jersey | 20,073 | $367 |
| FMR LLC | 19,168 | $350 |
| ROYAL BANK OF CANADA | 19,047 | $348 |
| LEVIN CAPITAL STRATEGIES, L.P. | 19,000 | $347 |
| 63 other institutions | 310,729 | $5,350 |