FRACTYL HEALTH INC

Ticker: GUTS CUSIP: 35168W103 Class: Common Stock

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (32)

Pale Fire Capital SE
Value ($000) $7,062 Shares 3,209,942
Atom Investors LP
Value ($000) $4,143 Shares 1,883,018
Newtyn Management, LLC
Value ($000) $2,495 Shares 1,134,021
TWO SIGMA INVESTMENTS, LP
Value ($000) $4,048 Shares 1,840,136
TWO SIGMA ADVISERS, LP
Value ($000) $2,857 Shares 1,298,700
Brevan Howard Capital Management LP
Value ($000) $1,048 Shares 464,738
Quantbot Technologies LP
Value ($000) $265 Shares 120,434
Walleye Capital LLC
Value ($000) $1,303 Shares 592,125
JANE STREET GROUP, LLC
Value ($000) $4,098 Shares 1,862,600
ExodusPoint Capital Management, LP
Value ($000) $392 Shares 178,024
OMERS ADMINISTRATION Corp
Value ($000) $394 Shares 179,300
SUSQUEHANNA INTERNATIONAL GROUP, LLP
Value ($000) $1,759 Shares 799,457
Hudson Bay Capital Management LP
Value ($000) $378 Shares 171,816
Lighthouse Investment Partners, LLC
Value ($000) $80 Shares 36,300
Squarepoint Ops LLC
Value ($000) $325 Shares 147,659
Bronte Capital Management Pty Ltd.
Value ($000) $37 Shares 16,905
Susquehanna Portfolio Strategies, LLC
Value ($000) $108 Shares 49,137
Verition Fund Management LLC
Value ($000) $121 Shares 54,910
Schonfeld Strategic Advisors LLC
Value ($000) $110 Shares 50,204
BALYASNY ASSET MANAGEMENT L.P.
Value ($000) $132 Shares 60,219

Increased Positions (32)

CM Management, LLC
Value ($000) $1,760 (+84.5%) Shares 800,000 (+33.3%)
Catalio Capital Management, LP
Value ($000) $12,082 (+45.7%) Shares 5,491,866 (+5.3%)
Diametric Capital, LP
Value ($000) $1,107 (+454.4%) Shares 503,409 (+300.7%)
683 Capital Management, LLC
Value ($000) $13,305 (+80.0%) Shares 6,047,620 (+30.1%)
Logos Global Management LP
Value ($000) $2,420 (+204.4%) Shares 1,100,000 (+120.0%)
MARSHALL WACE, LLP
Value ($000) $13,039 (+363.4%) Shares 5,926,745 (+234.9%)
Quadrature Capital Ltd
Value ($000) $640 (+2889.6%) Shares 290,714 (+2047.1%)
RENAISSANCE TECHNOLOGIES LLC
Value ($000) $4,099 (+231.9%) Shares 1,863,051 (+139.9%)
GOLDMAN SACHS GROUP INC
Value ($000) $7,535 (+866.3%) Shares 3,425,197 (+598.4%)
VANGUARD GROUP INC
Value ($000) $13,262 (+334.2%) Shares 6,028,179 (+213.8%)
MILLENNIUM MANAGEMENT LLC
Value ($000) $4,095 (+531.8%) Shares 1,861,418 (+356.6%)
D. E. Shaw & Co., Inc.
Value ($000) $3,174 (+578.3%) Shares 1,442,745 (+390.2%)
PRELUDE CAPITAL MANAGEMENT, LLC
Value ($000) $177 (+220.9%) Shares 80,597 (+131.9%)
BlackRock, Inc.
Value ($000) $4,583 (+279.3%) Shares 2,083,318 (+174.1%)
BANK OF AMERICA CORP /DE/
Value ($000) $2,623 (+1761.2%) Shares 1,192,236 (+1245.1%)
GEODE CAPITAL MANAGEMENT, LLC
Value ($000) $2,782 (+493.2%) Shares 1,263,855 (+328.5%)
STATE STREET CORP
Value ($000) $1,128 (+1638.7%) Shares 512,700 (+1156.6%)
UBS Group AG
Value ($000) $2,451 (+104.8%) Shares 1,113,982 (+48.0%)
BARCLAYS PLC
Value ($000) $535 (+342.6%) Shares 243,294 (+409.0%)
MORGAN STANLEY
Value ($000) $1,444 (+111.1%) Shares 656,482 (+52.6%)

Decreased Positions (17)

Rosalind Advisors, Inc.
Value ($000) $849 (-89.3%) Shares 385,731 (-92.3%)
SILVERARC CAPITAL MANAGEMENT, LLC
Value ($000) $21,648 (+28.4%) Shares 9,840,041 (-7.2%)
Nantahala Capital Management, LLC
Value ($000) $23,862 (+23.7%) Shares 10,846,440 (-10.6%)
Soleus Capital Management, L.P.
Value ($000) $880 (-77.9%) Shares 400,000 (-84.0%)
Ikarian Capital, LLC
Value ($000) $2,420 (-15.4%) Shares 1,100,000 (-38.9%)
Shay Capital LLC
Value ($000) $300 (-33.7%) Shares 136,568 (-52.1%)
Alyeska Investment Group, L.P.
Value ($000) $8,381 (-6.7%) Shares 3,809,523 (-32.6%)
BOOTHBAY FUND MANAGEMENT, LLC
Value ($000) $605 (-41.9%) Shares 275,219 (-58.0%)
Point72 Asset Management, L.P.
Value ($000) $803 (-76.9%) Shares 365,173 (-83.3%)
Scientech Research LLC
Value ($000) $40 (-18.5%) Shares 18,006 (-41.1%)
CITADEL ADVISORS LLC
Value ($000) $504 (-82.2%) Shares 228,985 (-87.2%)
MASSACHUSETTS FINANCIAL SERVICES CO /MA/
Value ($000) $1,875 (+27.4%) Shares 852,344 (-7.9%)
PEAK6 LLC
Value ($000) $440 (+10.7%) Shares 200,000 (-20.0%)
JPMORGAN CHASE & CO
Value ($000) $2 (-97.5%) Shares 934 (-98.2%)
Centiva Capital, LP
Value ($000) $38 (-51.2%) Shares 17,419 (-64.7%)
OSAIC HOLDINGS, INC.
Value ($000) $166 (+110.2%) Shares 75,476 (-1.7%)
BNP PARIBAS ARBITRAGE, SA
Value ($000) $2 (+21.2%) Shares 802 (-12.3%)

Exited Positions (8)

Alphabet Inc.
Value ($000) $1,054 Shares 662,584
Arrowpoint Investment Partners (Singapore) Pte. Ltd.
Value ($000) $56 Shares 35,000
STONERIDGE INVESTMENT PARTNERS LLC
Value ($000) $0 Shares 23,721
ADAR1 Capital Management, LLC
Value ($000) $21 Shares 13,097
HRT FINANCIAL LP
Value ($000) $1 Shares 614,792
EverSource Wealth Advisors, LLC
Value ($000) $0 Shares 39
ROYAL BANK OF CANADA
Value ($000) $0 Shares 196
CWM, LLC
Value ($000) $0 Shares 149