GINKGO BIOWORKS HOLDINGS INC

Ticker: DNA CUSIP: 37611X209 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 500,000 Value ($000) $5,625 Avg Close $7.75 Range $5.00 - $11.50

Q1 2025

Shares 1,195,000 Value ($000) $6,812 Avg Close $10.19 Range $5.52 - $16.85

Q4 2024

Shares 1,200,000 Value ($000) $11,784 Avg Close $8.57 Range $6.01 - $11.98

Q3 2024

Shares 820,202 Value ($000) $6,685 Avg Close $10.02 Range $5.26 - $16.40

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	500,000	$5,625	$7.75	$5.00 - $11.50
Q1 2025	1,195,000	$6,812	$10.19	$5.52 - $16.85
Q4 2024	1,200,000	$11,784	$8.57	$6.01 - $11.98
Q3 2024	820,202	$6,685	$10.02	$5.26 - $16.40