GLOBAL BLOOD THERAPEUTICS IN

CUSIP: 37890U108 Class: COMMON STOCK

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2020
Shares 24,752 Value ($000) $1,265 Avg Close — Range —
Q1 2019
Shares 80,000 Value ($000) $4,234 Avg Close — Range —
Q4 2018
Shares 147,000 Value ($000) $6,034 Avg Close — Range —
Q4 2017
Shares 100,000 Value ($000) $3,935 Avg Close — Range —
Q3 2017
Shares 127,000 Value ($000) $3,943 Avg Close — Range —
Q2 2017
Shares 150,000 Value ($000) $4,103 Avg Close — Range —
Q4 2016
Shares 125,000 Value ($000) $1,806 Avg Close — Range —