GLOBAL BLOOD THERAPEUTICS IN

CUSIP: 37890U108 Class: COMMON STOCK

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q2 2017
Shares 40,000 Value ($000) $1,094 Avg Close — Range —
Q3 2016
Shares 200,000 Value ($000) $4,610 Avg Close — Range —
Q2 2016
Shares 152,000 Value ($000) $2,522 Avg Close — Range —