GRAIL INC

Ticker: GRAL CUSIP: 384747101 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 101,449 Value ($000) $8,683 Avg Close $86.40 Range $58.50 - $115.76

Q3 2025

Shares 147,032 Value ($000) $8,694 Avg Close $38.21 Range $29.95 - $59.70

Q2 2025

Shares 253,620 Value ($000) $13,041 Avg Close $36.20 Range $20.44 - $52.56

Q1 2025

Shares 266,089 Value ($000) $6,796 Avg Close $30.90 Range $16.56 - $63.99

Q4 2024

Shares 96,630 Value ($000) $1,725 Avg Close $16.26 Range $12.33 - $24.92

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	101,449	$8,683	$86.40	$58.50 - $115.76
Q3 2025	147,032	$8,694	$38.21	$29.95 - $59.70
Q2 2025	253,620	$13,041	$36.20	$20.44 - $52.56
Q1 2025	266,089	$6,796	$30.90	$16.56 - $63.99
Q4 2024	96,630	$1,725	$16.26	$12.33 - $24.92