| BlackRock, Inc. | 2,958,246 | $253,196 |
| FARALLON CAPITAL MANAGEMENT LLC | 2,342,684 | $200,510 |
| BAKER BROS. ADVISORS LP | 2,085,333 | $178,484 |
| VANGUARD GROUP INC | 1,980,783 | $169,535 |
| PRIMECAP MANAGEMENT CO/CA/ | 1,838,684 | $157,373 |
| STATE STREET CORP | 1,827,523 | $156,418 |
| MORGAN STANLEY | 1,511,687 | $129,385 |
| CRCM LP | 1,072,374 | $91,784 |
| Arbiter Partners Capital Management LLC | 1,035,597 | $88,637 |
| Deep Track Capital, LP | 1,022,797 | $87,541 |
| GEODE CAPITAL MANAGEMENT, LLC | 801,503 | $68,609 |
| BANK OF AMERICA CORP /DE/ | 708,503 | $60,641 |
| GOLDMAN SACHS GROUP INC | 536,986 | $45,961 |
| Alyeska Investment Group, L.P. | 442,500 | $37,874 |
| RA CAPITAL MANAGEMENT, L.P. | 428,266 | $36,655 |
| Sessa Capital IM, L.P. | 364,714 | $31,216 |
| NORTHERN TRUST CORP | 341,427 | $29,223 |
| AQR CAPITAL MANAGEMENT LLC | 326,845 | $27,860 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 270,827 | $23,180 |
| Allianz Asset Management GmbH | 267,560 | $22,900 |
| RAYMOND JAMES FINANCIAL INC | 258,810 | $22,152 |
| PERCEPTIVE ADVISORS LLC | 237,342 | $20,314 |
| DIMENSIONAL FUND ADVISORS LP | 216,793 | $18,555 |
| UBS Group AG | 213,178 | $18,246 |
| Carnegie Capital Asset Management, LLC | 213,050 | $18,235 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 210,768 | $18 |
| TCW GROUP INC | 197,313 | $16,888 |
| FMR LLC | 163,244 | $13,972 |
| Slow Capital, Inc. | 162,417 | $13,901 |
| Douglas Lane & Associates, LLC | 161,624 | $13,833 |
| BIT Capital GmbH | 156,263 | $13,375 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 152,574 | $13,059 |
| Newtyn Management, LLC | 150,000 | $12,839 |
| Voleon Capital Management LP | 147,906 | $12,659 |
| FRANKLIN RESOURCES INC | 146,135 | $12,508 |
| BRAIDWELL LP | 142,755 | $12,218 |
| JPMORGAN CHASE & CO | 141,478 | $12,109 |
| Invesco Ltd. | 137,967 | $11,809 |
| Bank of New York Mellon Corp | 135,808 | $11,624 |
| BARCLAYS PLC | 125,658 | $10,755 |
| abrdn plc | 124,928 | $10,693 |
| 180 WEALTH ADVISORS, LLC | 115,047 | $9,847 |
| CAPITAL FUND MANAGEMENT S.A. | 113,207 | $9,689 |
| Reynders McVeigh Capital Management, LLC | 112,869 | $10 |
| FIRST TRUST ADVISORS LP | 108,325 | $9,272 |
| WIM INVESTMENT MANAGEMENT Ltd | 106,400 | $9,107 |
| TWO SIGMA INVESTMENTS, LP | 101,449 | $8,683 |
| Blue Water Life Science Advisors, LP | 99,000 | $8,473 |
| RENAISSANCE TECHNOLOGIES LLC | 85,300 | $7,301 |
| AMERICAN CENTURY COMPANIES INC | 81,476 | $6,974 |
| Swiss National Bank | 72,300 | $6,188 |
| Nuveen, LLC | 70,850 | $6,064 |
| Rockefeller Capital Management L.P. | 68,577 | $5,870 |
| Legal & General Group Plc | 68,349 | $5,850 |
| CITIGROUP INC | 67,534 | $5,780 |
| CITADEL ADVISORS LLC | 67,427 | $5,771 |
| WELLS FARGO & COMPANY/MN | 65,336 | $5,592 |
| UBS ASSET MANAGEMENT AMERICAS INC | 61,611 | $5,273 |
| Rafferty Asset Management, LLC | 61,284 | $5,245 |
| Public Sector Pension Investment Board | 55,855 | $4,781 |
| ROYAL BANK OF CANADA | 54,335 | $4,650 |
| Pier Capital, LLC | 51,836 | $4,437 |
| Granahan Investment Management, LLC | 50,508 | $4,323 |
| Verition Fund Management LLC | 47,528 | $4,068 |
| RHUMBLINE ADVISERS | 47,095 | $4,031 |
| GILDER GAGNON HOWE & CO LLC | 43,722 | $3,742 |
| AMERIPRISE FINANCIAL INC | 41,016 | $3,511 |
| Pictet Asset Management Holding SA | 40,926 | $3,585 |
| D. E. Shaw & Co., Inc. | 40,280 | $3,448 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 38,495 | $3,295 |
| ALLIANCEBERNSTEIN L.P. | 38,351 | $3,282 |
| VICTORY CAPITAL MANAGEMENT INC | 37,765 | $3,232 |
| STIFEL FINANCIAL CORP | 37,369 | $3,198 |
| LPL Financial LLC | 36,001 | $3,081 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,774 | $2,976 |
| Legal Advantage Investments, Inc. | 33,500 | $2,867 |
| Jackson Hole Capital Partners, LLC | 33,000 | $2,824 |
| T. Rowe Price Investment Management, Inc. | 32,782 | $3 |
| GABELLI FUNDS LLC | 31,650 | $2,709 |
| Baird Financial Group, Inc. | 31,074 | $2,660 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 30,918 | $3,215 |
| Catalio Capital Management, LP | 30,313 | $2,594 |
| EAM Investors, LLC | 29,692 | $2,541 |
| OSAIC HOLDINGS, INC. | 29,266 | $2,505 |
| Mutual Advisors, LLC | 29,136 | $2,494 |
| IEQ CAPITAL, LLC | 28,522 | $2,441 |
| DEUTSCHE BANK AG\ | 28,509 | $2,440 |
| TUDOR INVESTMENT CORP ET AL | 28,450 | $2,435 |
| VAN ECK ASSOCIATES CORP | 27,533 | $2 |
| COMMERCE BANK | 26,867 | $2,300 |
| PRUDENTIAL FINANCIAL INC | 25,095 | $2,148 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 25,013 | $2,141 |
| GAMCO INVESTORS, INC. ET AL | 24,658 | $2,110 |
| Gotham Asset Management, LLC | 23,282 | $1,993 |
| Blackstone Inc. | 23,036 | $1,972 |
| STATE OF WISCONSIN INVESTMENT BOARD | 23,002 | $1,969 |
| Banque Transatlantique SA | 23,000 | $1,969 |
| PROFUND ADVISORS LLC | 22,776 | $1,949 |
| NWF Advisory Services Inc. | 22,070 | $1,889 |
| Mariner, LLC | 21,759 | $1,862 |
| 315 other institutions | 1,181,278 | $95,014 |