| FMR LLC | 16,549,716 | $355,488 |
| BlackRock, Inc. | 7,594,996 | $163,141 |
| Point72 Asset Management, L.P. | 7,034,952 | $151,111 |
| VANGUARD GROUP INC | 6,038,414 | $129,705 |
| Redmile Group, LLC | 5,718,385 | $122,831 |
| Enavate Sciences GP, LLC | 4,768,583 | $102,429 |
| PRIMECAP MANAGEMENT CO/CA/ | 4,685,441 | $100,643 |
| STATE STREET CORP | 3,868,000 | $83,085 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 3,705,974 | $79,604 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,380,240 | $73 |
| JPMORGAN CHASE & CO | 2,855,747 | $61,341 |
| EcoR1 Capital, LLC | 2,855,590 | $61,338 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,361,381 | $50,731 |
| Jefferies Financial Group Inc. | 2,000,000 | $42,960 |
| READYSTATE ASSET MANAGEMENT LP | 1,843,210 | $39,592 |
| CITADEL ADVISORS LLC | 1,740,705 | $37,390 |
| MORGAN STANLEY | 1,709,089 | $36,711 |
| Sofinnova Investments, Inc. | 1,618,477 | $34,765 |
| Woodline Partners LP | 1,575,398 | $33,840 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,429,680 | $30,710 |
| PRINCIPAL FINANCIAL GROUP INC | 1,404,450 | $30,168 |
| T. Rowe Price Investment Management, Inc. | 1,216,553 | $26 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,126,210 | $24,191 |
| WELLINGTON MANAGEMENT GROUP LLP | 934,463 | $20,072 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 840,689 | $18,058 |
| JANUS HENDERSON GROUP PLC | 832,078 | $17,874 |
| NORTHERN TRUST CORP | 828,701 | $17,800 |
| Polar Capital Holdings Plc | 793,364 | $17,041 |
| ExodusPoint Capital Management, LP | 779,578 | $16,745 |
| TD Asset Management Inc | 759,192 | $16,307 |
| GOLDMAN SACHS GROUP INC | 752,725 | $16,169 |
| MARSHALL WACE, LLP | 737,116 | $15,833 |
| Pivotal bioVenture Partners Investment Advisor LLC | 732,512 | $15,734 |
| NAN FUNG TRINITY (HK) LTD | 714,553 | $15,349 |
| Candriam S.C.A. | 539,882 | $11,597 |
| Granahan Investment Management, LLC | 435,123 | $9,346 |
| Rock Springs Capital Management LP | 347,666 | $7,468 |
| Atika Capital Management LLC | 334,341 | $7,182 |
| DIMENSIONAL FUND ADVISORS LP | 316,383 | $6,796 |
| UBS Group AG | 307,194 | $6,599 |
| Alyeska Investment Group, L.P. | 293,750 | $6,310 |
| KENNEDY CAPITAL MANAGEMENT LLC | 286,355 | $6,151 |
| Parkman Healthcare Partners LLC | 277,812 | $5,967 |
| Monashee Investment Management LLC | 274,861 | $5,904 |
| Invesco Ltd. | 270,065 | $5,801 |
| Bank of New York Mellon Corp | 263,374 | $5,657 |
| BARCLAYS PLC | 246,065 | $5,285 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 237,270 | $5,035 |
| BANK OF AMERICA CORP /DE/ | 202,717 | $4,354 |
| Burkehill Global Management, LP | 200,000 | $4,296 |
| Neo Ivy Capital Management | 192,635 | $4,138 |
| AMERIPRISE FINANCIAL INC | 190,562 | $4,093 |
| Swiss National Bank | 185,000 | $3,974 |
| BNP Paribas Investment Partners S.A. | 182,379 | $4 |
| Atom Investors LP | 175,767 | $3,775 |
| GILDER GAGNON HOWE & CO LLC | 174,861 | $3,756 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 170,914 | $3,671 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 170,002 | $3,652 |
| Nuveen, LLC | 169,346 | $3,638 |
| SG Americas Securities, LLC | 162,168 | $3 |
| Trexquant Investment LP | 130,834 | $2,810 |
| Birchview Capital, LP | 130,000 | $2,792 |
| SummitTX Capital, L.P. | 127,613 | $2,741 |
| UBS ASSET MANAGEMENT AMERICAS INC | 123,749 | $2,658 |
| RHUMBLINE ADVISERS | 113,565 | $2,439 |
| Rafferty Asset Management, LLC | 113,395 | $2,436 |
| WELLS FARGO & COMPANY/MN | 108,115 | $2,322 |
| NEOS Investment Management LLC | 103,585 | $2,225 |
| Longaeva Partners L.P. | 102,500 | $2,202 |
| TEMA ETFS LLC | 102,055 | $2,192 |
| LMR Partners LLP | 100,000 | $2,148 |
| AMERICAN CENTURY COMPANIES INC | 98,136 | $2,108 |
| Legal & General Group Plc | 94,958 | $2,040 |
| ALLIANCEBERNSTEIN L.P. | 92,990 | $1,997 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 82,577 | $1,774 |
| NISA INVESTMENT ADVISORS, LLC | 80,228 | $1,723 |
| DEUTSCHE BANK AG\ | 76,242 | $1,638 |
| Maven Securities LTD | 75,000 | $1,611 |
| Verition Fund Management LLC | 72,864 | $1,565 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,012 | $1,439 |
| Freestone Capital Holdings, LLC | 61,549 | $1,322 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 59,417 | $949 |
| Lido Advisors, LLC | 59,051 | $691 |
| DARK FOREST CAPITAL MANAGEMENT LP | 57,153 | $1,228 |
| MetLife Investment Management, LLC | 52,034 | $1,118 |
| Erste Asset Management GmbH | 52,000 | $1,123 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,137 | $1,075 |
| AlphaQuest LLC | 48,968 | $1,052 |
| Baldwin Investment Management, LLC | 47,167 | $1,013 |
| RAYMOND JAMES FINANCIAL INC | 46,569 | $1,000 |
| Magnus Financial Group LLC | 45,759 | $983 |
| STATE OF WISCONSIN INVESTMENT BOARD | 45,743 | $983 |
| SCHARF INVESTMENTS, LLC | 44,389 | $953 |
| Susquehanna Portfolio Strategies, LLC | 44,164 | $949 |
| Corient Private Wealth LLC | 43,203 | $928 |
| Cerity Partners LLC | 42,792 | $919 |
| PROFUND ADVISORS LLC | 42,700 | $917 |
| Three Bridge Wealth Advisors, LLC | 37,615 | $808 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 35,431 | $761 |
| Schonfeld Strategic Advisors LLC | 32,099 | $689 |
| 81 other institutions | 778,777 | $16,231 |