| RTW INVESTMENTS, LP | 4,869,798 | $169,031 |
| WELLINGTON MANAGEMENT GROUP LLP | 4,693,643 | $162,916 |
| FMR LLC | 4,539,225 | $157,556 |
| PRIMECAP MANAGEMENT CO/CA/ | 3,961,880 | $137,517 |
| Bellevue Group AG | 2,796,803 | $97,077 |
| TANG CAPITAL MANAGEMENT LLC | 2,628,538 | $91,237 |
| BAKER BROS. ADVISORS LP | 2,322,656 | $80,619 |
| Deep Track Capital, LP | 2,003,978 | $69,558 |
| BVF INC/IL | 1,488,975 | $50,294 |
| ARMISTICE CAPITAL, LLC | 1,098,000 | $38,112 |
| Fiera Capital Corp | 1,044,831 | $36,266 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 968,784 | $34 |
| MILLENNIUM MANAGEMENT LLC | 911,597 | $31,642 |
| T. Rowe Price Investment Management, Inc. | 873,628 | $30 |
| Kynam Capital Management, LP | 856,462 | $29,728 |
| Logos Global Management LP | 850,000 | $29,504 |
| Trails Edge Capital Partners, LP | 682,597 | $23,693 |
| PRINCIPAL FINANCIAL GROUP INC | 658,436 | $22,854 |
| Vestal Point Capital, LP | 585,000 | $20,305 |
| Point72 Asset Management, L.P. | 504,151 | $17,499 |
| ACADIAN ASSET MANAGEMENT LLC | 461,830 | $16 |
| JANUS HENDERSON GROUP PLC | 454,404 | $15,734 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 407,404 | $14,141 |
| Frazier Life Sciences Management, L.P. | 384,782 | $13,356 |
| Hudson Bay Capital Management LP | 383,558 | $13,313 |
| TWO SIGMA INVESTMENTS, LP | 359,293 | $12,471 |
| BlackRock, Inc. | 329,099 | $11,423 |
| TWO SIGMA ADVISERS, LP | 322,300 | $11,187 |
| Woodline Partners LP | 316,685 | $10,992 |
| TD Asset Management Inc | 292,764 | $10,162 |
| MORGAN STANLEY | 287,125 | $9,966 |
| Candriam S.C.A. | 269,729 | $9,363 |
| BANK OF AMERICA CORP /DE/ | 234,737 | $8,148 |
| CITADEL ADVISORS LLC | 234,268 | $8,131 |
| NEW YORK STATE COMMON RETIREMENT FUND | 211,140 | $7,329 |
| D. E. Shaw & Co., Inc. | 183,940 | $6,385 |
| Rhenman & Partners Asset Management AB | 153,278 | $5,320 |
| Legal & General Group Plc | 149,333 | $5,183 |
| RENAISSANCE TECHNOLOGIES LLC | 140,900 | $4,891 |
| AMERIPRISE FINANCIAL INC | 135,207 | $4,693 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 109,849 | $3,813 |
| BARCLAYS PLC | 103,253 | $3,584 |
| JANE STREET GROUP, LLC | 100,940 | $3,504 |
| BNP Paribas Investment Partners S.A. | 95,904 | $3 |
| Caption Management, LLC | 94,384 | $3,276 |
| STATE STREET CORP | 93,556 | $3,247 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 85,169 | $2,909 |
| Eschler Asset Management LLP | 80,000 | $2,777 |
| WELLS FARGO & COMPANY/MN | 77,228 | $2,681 |
| Exome Asset Management LLC | 76,750 | $2,664 |
| DIADEMA PARTNERS LP | 70,300 | $2,440 |
| MARSHALL WACE, LLP | 61,163 | $2,123 |
| Jump Financial, LLC | 61,150 | $2,123 |
| Elmind Capital, LP | 58,248 | $2,022 |
| ENVESTNET ASSET MANAGEMENT INC | 55,190 | $1,916 |
| SEI INVESTMENTS CO | 50,337 | $1,747 |
| Hennion & Walsh Asset Management, Inc. | 48,585 | $1,686 |
| Y-Intercept (Hong Kong) Ltd | 48,187 | $1,673 |
| Eagle Health Investments LP | 46,300 | $1,607 |
| GEODE CAPITAL MANAGEMENT, LLC | 43,026 | $1,493 |
| ROYAL BANK OF CANADA | 42,486 | $1,475 |
| HUSSMAN STRATEGIC ADVISORS, INC. | 42,000 | $1,458 |
| ALPS ADVISORS INC | 41,487 | $1,440 |
| Quadrature Capital Ltd | 38,608 | $1,340 |
| Crossmark Global Holdings, Inc. | 36,406 | $1,264 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,188 | $1,221 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 33,579 | $1,166 |
| HighVista Strategies LLC | 32,998 | $1,145 |
| HRT FINANCIAL LP | 32,596 | $1 |
| GOLDMAN SACHS GROUP INC | 32,390 | $1,124 |
| ASSETMARK, INC | 31,676 | $1,099 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 28,164 | $978 |
| Persistent Asset Partners Ltd | 27,932 | $970 |
| State of New Jersey Common Pension Fund D | 27,663 | $960 |
| Schonfeld Strategic Advisors LLC | 27,648 | $960 |
| Susquehanna Portfolio Strategies, LLC | 27,607 | $958 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 25,163 | $873 |
| Aquatic Capital Management LLC | 24,975 | $867 |
| NEOS Investment Management LLC | 22,599 | $784 |
| TUDOR INVESTMENT CORP ET AL | 22,231 | $772 |
| Brinker Capital Investments, LLC | 22,000 | $764 |
| XTX Topco Ltd | 21,991 | $763 |
| BNP PARIBAS ARBITRAGE, SA | 20,182 | $701 |
| Virtus Investment Advisers, LLC | 18,569 | $645 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16,507 | $573 |
| Squarepoint Ops LLC | 15,388 | $534 |
| China Universal Asset Management Co., Ltd. | 15,109 | $524 |
| DekaBank Deutsche Girozentrale | 15,000 | $1 |
| PSP Research LLC | 14,424 | $501 |
| DnB Asset Management AS | 13,066 | $454 |
| STIFEL FINANCIAL CORP | 11,661 | $405 |
| Bridgewater Associates, LP | 9,952 | $345 |
| Graham Capital Management, L.P. | 9,703 | $337 |
| R Squared Ltd | 8,849 | $307 |
| SG Americas Securities, LLC | 8,659 | $0 |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 8,180 | $284 |
| UBS Group AG | 7,218 | $251 |
| Snowden Capital Advisors LLC | 6,970 | $242 |
| CITIGROUP INC | 6,900 | $239 |
| LAZARD ASSET MANAGEMENT LLC | 6,839 | $237 |
| 49 other institutions | 61,434 | $2,027 |