| FMR LLC | 16,990,754 | $431,905 |
| Deep Track Capital, LP | 11,526,971 | $293,016 |
| VANGUARD GROUP INC | 7,779,314 | $197,750 |
| BlackRock, Inc. | 6,058,216 | $154,000 |
| ARMISTICE CAPITAL, LLC | 5,747,155 | $146,093 |
| BAKER BROS. ADVISORS LP | 5,457,881 | $138,739 |
| MORGAN STANLEY | 4,846,385 | $123,195 |
| STATE STREET CORP | 3,786,926 | $96,264 |
| RTW INVESTMENTS, LP | 3,177,850 | $80,781 |
| Two Seas Capital LP | 2,866,962 | $72,878 |
| Alpine Global Management, LLC | 2,626,692 | $66,771 |
| ADAR1 Capital Management, LLC | 2,480,968 | $63,066 |
| Point72 Asset Management, L.P. | 2,000,000 | $50,840 |
| PERCEPTIVE ADVISORS LLC | 1,994,890 | $50,710 |
| Woodline Partners LP | 1,975,869 | $50,227 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,857,532 | $47,227 |
| TCG Crossover Management, LLC | 1,660,933 | $42,221 |
| Logos Global Management LP | 1,375,000 | $34,953 |
| GOLDMAN SACHS GROUP INC | 1,296,008 | $32,945 |
| abrdn plc | 1,184,122 | $30,100 |
| Soleus Capital Management, L.P. | 1,110,000 | $28,216 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 893,056 | $23 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 863,000 | $21,937 |
| GREAT POINT PARTNERS LLC | 750,000 | $19,065 |
| UBS Group AG | 732,386 | $18,617 |
| JENNISON ASSOCIATES LLC | 700,464 | $17,806 |
| Candriam S.C.A. | 680,372 | $17,296 |
| STEMPOINT CAPITAL LP | 644,959 | $16,395 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 642,974 | $16,344 |
| T. Rowe Price Investment Management, Inc. | 573,463 | $15 |
| NORTHERN TRUST CORP | 566,148 | $14,391 |
| Connor, Clark & Lunn Investment Management Ltd. | 467,469 | $11,883 |
| Pictet Asset Management Holding SA | 380,842 | $9,681 |
| BNP PARIBAS ARBITRAGE, SA | 353,056 | $8,975 |
| BANK OF AMERICA CORP /DE/ | 313,481 | $7,969 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 288,677 | $7,338 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 259,117 | $6,587 |
| Prosight Management, LP | 243,404 | $6,187 |
| Trails Edge Capital Partners, LP | 240,165 | $6,105 |
| BARCLAYS PLC | 232,326 | $5,906 |
| Granahan Investment Management, LLC | 230,188 | $5,851 |
| Nuveen, LLC | 226,489 | $5,757 |
| TD Asset Management Inc | 224,960 | $5,718 |
| HighVista Strategies LLC | 221,883 | $5,640 |
| Assenagon Asset Management S.A. | 205,219 | $5,217 |
| Affinity Asset Advisors, LLC | 200,000 | $5,084 |
| Bank of New York Mellon Corp | 199,364 | $5,068 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 181,774 | $4,621 |
| MILLENNIUM MANAGEMENT LLC | 172,496 | $4,385 |
| Tetragon Partners GP Ltd | 166,187 | $4,224 |
| DIMENSIONAL FUND ADVISORS LP | 160,442 | $4,078 |
| Exome Asset Management LLC | 158,622 | $4,032 |
| Swiss National Bank | 158,300 | $4,024 |
| CITADEL ADVISORS LLC | 154,507 | $3,928 |
| DAFNA Capital Management LLC | 150,524 | $3,826 |
| UBS ASSET MANAGEMENT AMERICAS INC | 134,441 | $3,417 |
| Rafferty Asset Management, LLC | 132,346 | $3,364 |
| Erste Asset Management GmbH | 128,500 | $3,291 |
| ExodusPoint Capital Management, LP | 126,621 | $3,219 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 122,100 | $3,104 |
| Trexquant Investment LP | 114,995 | $2,923 |
| BANQUE PICTET & CIE SA | 114,881 | $2,920 |
| Jump Financial, LLC | 104,602 | $2,659 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 97,234 | $2,467 |
| Legal & General Group Plc | 92,714 | $2,357 |
| ALLIANCEBERNSTEIN L.P. | 89,160 | $2,266 |
| Invesco Ltd. | 88,857 | $2,259 |
| RHUMBLINE ADVISERS | 86,847 | $2,208 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 85,952 | $2,185 |
| HRT FINANCIAL LP | 84,840 | $2 |
| Verition Fund Management LLC | 80,794 | $2,054 |
| JPMORGAN CHASE & CO | 79,866 | $2,030 |
| Blackstone Inc. | 79,673 | $2,025 |
| WELLS FARGO & COMPANY/MN | 79,667 | $2,025 |
| Hennion & Walsh Asset Management, Inc. | 71,705 | $1,823 |
| ArrowMark Colorado Holdings LLC | 70,000 | $1,779 |
| Amundi | 67,404 | $1,713 |
| DEUTSCHE BANK AG\ | 62,458 | $1,588 |
| Quinn Opportunity Partners LLC | 61,108 | $1,553 |
| Alchemi Wealth, LLC | 56,576 | $1,438 |
| Voya Investment Management LLC | 53,631 | $1,363 |
| PROFUND ADVISORS LLC | 49,076 | $1,248 |
| SIMPLEX TRADING, LLC | 48,411 | $1,231 |
| SG Americas Securities, LLC | 45,648 | $1 |
| GSA CAPITAL PARTNERS LLP | 44,140 | $1 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 41,683 | $1,060 |
| Creative Planning | 41,501 | $1,055 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,305 | $1,024 |
| MetLife Investment Management, LLC | 39,036 | $992 |
| STATE OF WISCONSIN INVESTMENT BOARD | 38,919 | $989 |
| INTECH INVESTMENT MANAGEMENT LLC | 35,189 | $895 |
| JANUS HENDERSON GROUP PLC | 33,731 | $857 |
| HighTower Advisors, LLC | 33,408 | $849 |
| XTX Topco Ltd | 33,122 | $842 |
| DekaBank Deutsche Girozentrale | 32,600 | $1 |
| Handelsbanken Fonder AB | 32,300 | $1 |
| Ishara Investments LP | 30,000 | $763 |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 29,205 | $742 |
| WELLINGTON MANAGEMENT GROUP LLP | 28,847 | $733 |
| China Universal Asset Management Co., Ltd. | 28,561 | $726 |
| 95 other institutions | 611,472 | $14,839 |