IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

MACKAY SHIELDS LLC's Holding History (CIK: 0000061227)

Note: Option positions (PUT/CALL) are excluded.

Q2 2019

Shares 17,220 Value ($000) $1,107 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 40,821 Value ($000) $3,314 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 33,621 Value ($000) $1,818 Avg Close $51.00 Range $43.27 - $59.81

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2019	17,220	$1,107	$70.69	$61.91 - $86.58
Q1 2019	40,821	$3,314	$64.51	$52.45 - $81.59
Q4 2018	33,621	$1,818	$51.00	$43.27 - $59.81