| FMR LLC | 24,072,101 | $1,904,344 |
| Capital World Investors | 17,961,299 | $1,420,918 |
| VANGUARD GROUP INC | 16,440,459 | $1,300,605 |
| BlackRock, Inc. | 10,647,863 | $842,352 |
| WELLINGTON MANAGEMENT GROUP LLP | 6,260,325 | $495,254 |
| T. Rowe Price Investment Management, Inc. | 5,789,863 | $458 |
| Bellevue Group AG | 4,802,199 | $379,902 |
| STATE STREET CORP | 3,974,865 | $314,452 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,148,849 | $249,158 |
| TWO SIGMA ADVISERS, LP | 3,052,111 | $241,453 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,987,840 | $236 |
| TWO SIGMA INVESTMENTS, LP | 2,658,646 | $210,325 |
| Tweedy, Browne Co LLC | 2,464,930 | $195,001 |
| JPMORGAN CHASE & CO | 2,304,792 | $182,332 |
| CITADEL ADVISORS LLC | 2,134,636 | $168,871 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,979,669 | $156,612 |
| BAKER BROS. ADVISORS LP | 1,791,841 | $141,753 |
| Deep Track Capital, LP | 1,700,000 | $134,487 |
| AMERICAN CENTURY COMPANIES INC | 1,617,106 | $127,929 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,541,841 | $121,975 |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 1,462,706 | $115,715 |
| Pictet Asset Management Holding SA | 1,418,491 | $112,476 |
| UBS ASSET MANAGEMENT AMERICAS INC | 1,388,567 | $109,850 |
| BNP Paribas Investment Partners S.A. | 1,352,837 | $107 |
| Polar Capital Holdings Plc | 1,333,424 | $105,487 |
| FRANKLIN RESOURCES INC | 1,321,345 | $104,532 |
| Invesco Ltd. | 1,269,290 | $100,414 |
| Artisan Partners Limited Partnership | 1,181,416 | $93,462 |
| ROYAL BANK OF CANADA | 1,118,797 | $88,509 |
| Connor, Clark & Lunn Investment Management Ltd. | 1,076,370 | $85,152 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,063,327 | $84,120 |
| UBS Group AG | 1,045,041 | $82,673 |
| MORGAN STANLEY | 1,019,906 | $80,685 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 864,892 | $68,422 |
| GOLDMAN SACHS GROUP INC | 855,966 | $67,715 |
| NOMURA HOLDINGS INC | 848,815 | $67,150 |
| NORTHERN TRUST CORP | 846,718 | $66,984 |
| BARCLAYS PLC | 842,871 | $66,680 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 812,747 | $64,296 |
| GW&K Investment Management, LLC | 786,668 | $62 |
| BANK OF AMERICA CORP /DE/ | 783,579 | $61,989 |
| TD Asset Management Inc | 773,184 | $61,167 |
| GROUPAMA ASSET MANAGMENT | 766,889 | $60,669 |
| Candriam S.C.A. | 677,629 | $53,610 |
| Nuveen, LLC | 660,769 | $52,273 |
| AMERIPRISE FINANCIAL INC | 598,748 | $47,367 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 584,970 | $46,277 |
| EVENTIDE ASSET MANAGEMENT, LLC | 575,000 | $45,488 |
| Tri Locum Partners LP | 557,174 | $44,078 |
| Eversept Partners, LP | 538,218 | $42,578 |
| Bank of New York Mellon Corp | 537,886 | $42,552 |
| FIRST TRUST ADVISORS LP | 525,239 | $41,552 |
| Alyeska Investment Group, L.P. | 481,711 | $38,108 |
| Hudson Bay Capital Management LP | 475,000 | $37,577 |
| PINNACLE ASSOCIATES LTD | 461,968 | $36,546 |
| Amundi | 460,947 | $36,466 |
| Squarepoint Ops LLC | 436,279 | $34,514 |
| ARK Investment Management LLC | 422,968 | $33,461 |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 422,899 | $33,456 |
| BOONE CAPITAL MANAGEMENT LLC | 417,833 | $33,055 |
| C WorldWide Group Holding A/S | 366,000 | $29 |
| Jain Global LLC | 356,259 | $28,184 |
| ALLIANCEBERNSTEIN L.P. | 341,849 | $27,044 |
| BNP PARIBAS ARBITRAGE, SA | 334,608 | $26,471 |
| D. E. Shaw & Co., Inc. | 332,803 | $26,328 |
| Legal & General Group Plc | 325,148 | $25,722 |
| NORGES BANK | 320,160 | $25,328 |
| Swiss National Bank | 298,500 | $23,614 |
| WELLS FARGO & COMPANY/MN | 280,045 | $22,154 |
| Zurich Insurance Group Ltd/FI | 261,820 | $20,713 |
| RAYMOND JAMES FINANCIAL INC | 257,210 | $20,348 |
| MARSHALL WACE, LLP | 256,933 | $20,326 |
| NEW YORK STATE COMMON RETIREMENT FUND | 241,853 | $19,133 |
| Privium Fund Management B.V. | 240,824 | $19,052 |
| Davern Capital Partners, LP | 238,477 | $18,866 |
| Orion Investment Co | 225,161 | $17,812 |
| RENAISSANCE TECHNOLOGIES LLC | 223,607 | $17,690 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 219,574 | $17,371 |
| DAVENPORT & Co LLC | 217,897 | $17,238 |
| Corient Private Wealth LLC | 214,936 | $17,004 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 213,368 | $16,880 |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 203,730 | $16,117 |
| Ikarian Capital, LLC | 202,038 | $15,983 |
| STIFEL FINANCIAL CORP | 198,863 | $15,732 |
| SECTOR GAMMA AS | 184,977 | $14,634 |
| Focus Partners Wealth | 181,817 | $14,384 |
| DIMENSIONAL FUND ADVISORS LP | 176,035 | $13,925 |
| RHUMBLINE ADVISERS | 175,387 | $13,875 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt | 167,657 | $13,263 |
| Man Group plc | 166,042 | $13,136 |
| Sicart Associates LLC | 163,557 | $12,939 |
| Rhenman & Partners Asset Management AB | 158,500 | $12,539 |
| CenterBook Partners LP | 153,949 | $12,179 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 153,241 | $12,105 |
| DEUTSCHE BANK AG\ | 149,443 | $11,822 |
| GREAT LAKES ADVISORS, LLC | 149,180 | $11,802 |
| ADAR1 Capital Management, LLC | 147,130 | $11,639 |
| Artia Global Partners LP | 144,376 | $11,422 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 144,173 | $11,406 |
| Fisher Asset Management, LLC | 141,615 | $11,203 |
| 388 other institutions | 7,567,750 | $543,486 |