IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

&PARTNERS's Holding History (CIK: 0000107136)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 9,723 Value ($000) $769 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 12,663 Value ($000) $828 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 11,758 Value ($000) $465 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 11,004 Value ($000) $343 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 10,317 Value ($000) $359 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 9,606 Value ($000) $385 Avg Close $46.53 Range $39.48 - $52.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	9,723	$769	$75.30	$64.93 - $83.61
Q3 2025	12,663	$828	$48.82	$39.72 - $65.55
Q2 2025	11,758	$465	$32.73	$23.95 - $40.61
Q1 2025	11,004	$343	$32.75	$29.61 - $35.48
Q4 2024	10,317	$359	$37.38	$33.33 - $40.58
Q3 2024	9,606	$385	$46.53	$39.48 - $52.34