IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

FIL Ltd's Holding History (CIK: 0000318989)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 47 Value ($000) $4 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 47 Value ($000) $3 Avg Close $48.82 Range $39.72 - $65.55

Q1 2016

Shares 33,916 Value ($000) $1,374 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 36,640 Value ($000) $2,269 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	47	$4	$75.30	$64.93 - $83.61
Q3 2025	47	$3	$48.82	$39.72 - $65.55
Q1 2016	33,916	$1,374	$40.62	$30.93 - $62.68
Q4 2015	36,640	$2,269	$53.96	$38.30 - $65.34