IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

FRONTIER CAPITAL MANAGEMENT CO LLC's Holding History (CIK: 0000351173)

Note: Option positions (PUT/CALL) are excluded.

Q1 2018

Shares 65,838 Value ($000) $2,902 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 65,797 Value ($000) $3,310 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 87,944 Value ($000) $4,459 Avg Close $52.38 Range $43.75 - $60.01

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2018	65,838	$2,902	$50.80	$43.38 - $56.47
Q4 2017	65,797	$3,310	$54.84	$50.02 - $65.51
Q3 2017	87,944	$4,459	$52.38	$43.75 - $60.01