IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY's Holding History (CIK: 0000714142)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 24,083 Value ($000) $2 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 24,083 Value ($000) $2 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 24,083 Value ($000) $1 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 24,083 Value ($000) $1 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 24,083 Value ($000) $1 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 24,083 Value ($000) $1 Avg Close $46.53 Range $39.48 - $52.34

Q2 2024

Shares 24,083 Value ($000) $1 Avg Close $41.01 Range $35.95 - $47.86

Q1 2024

Shares 24,083 Value ($000) $1 Avg Close $47.67 Range $41.60 - $54.44

Q4 2023

Shares 14,118 Value ($000) $1 Avg Close $47.90 Range $41.84 - $52.27

Q3 2023

Shares 14,118 Value ($000) $1 Avg Close $41.26 Range $38.26 - $47.72

Q3 2020

Shares 16,431 Value ($000) $780 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 31,255 Value ($000) $1,843 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 47,169 Value ($000) $2,230 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 77,567 Value ($000) $4,686 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 59,526 Value ($000) $3,566 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 53,394 Value ($000) $3,432 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 52,191 Value ($000) $4,236 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 55,714 Value ($000) $3,012 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 78,855 Value ($000) $4,067 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 81,189 Value ($000) $3,383 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 78,901 Value ($000) $3,478 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 104,288 Value ($000) $5,246 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 110,662 Value ($000) $5,611 Avg Close $52.38 Range $43.75 - $60.01

Q2 2017

Shares 111,862 Value ($000) $5,690 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 105,204 Value ($000) $4,230 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 95,782 Value ($000) $4,582 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 80,676 Value ($000) $2,956 Avg Close $31.29 Range $23.26 - $40.82

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	24,083	$2	$75.30	$64.93 - $83.61
Q3 2025	24,083	$2	$48.82	$39.72 - $65.55
Q2 2025	24,083	$1	$32.73	$23.95 - $40.61
Q1 2025	24,083	$1	$32.75	$29.61 - $35.48
Q4 2024	24,083	$1	$37.38	$33.33 - $40.58
Q3 2024	24,083	$1	$46.53	$39.48 - $52.34
Q2 2024	24,083	$1	$41.01	$35.95 - $47.86
Q1 2024	24,083	$1	$47.67	$41.60 - $54.44
Q4 2023	14,118	$1	$47.90	$41.84 - $52.27
Q3 2023	14,118	$1	$41.26	$38.26 - $47.72
Q3 2020	16,431	$780	$55.55	$47.19 - $63.49
Q2 2020	31,255	$1,843	$55.63	$45.12 - $61.24
Q1 2020	47,169	$2,230	$55.74	$39.32 - $64.34
Q4 2019	77,567	$4,686	$59.58	$53.34 - $66.22
Q3 2019	59,526	$3,566	$65.17	$58.48 - $73.09
Q2 2019	53,394	$3,432	$70.69	$61.91 - $86.58
Q1 2019	52,191	$4,236	$64.51	$52.45 - $81.59
Q4 2018	55,714	$3,012	$51.00	$43.27 - $59.81
Q3 2018	78,855	$4,067	$46.98	$41.05 - $54.85
Q2 2018	81,189	$3,383	$44.30	$39.07 - $51.00
Q1 2018	78,901	$3,478	$50.80	$43.38 - $56.47
Q4 2017	104,288	$5,246	$54.84	$50.02 - $65.51
Q3 2017	110,662	$5,611	$52.38	$43.75 - $60.01
Q2 2017	111,862	$5,690	$46.57	$37.26 - $55.73
Q1 2017	105,204	$4,230	$44.91	$37.29 - $56.91
Q4 2016	95,782	$4,582	$39.57	$24.58 - $57.00
Q3 2016	80,676	$2,956	$31.29	$23.26 - $40.82