IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

SIT INVESTMENT ASSOCIATES INC's Holding History (CIK: 0000769317)

Note: Option positions (PUT/CALL) are excluded.

Q2 2018

Shares 13,725 Value ($000) $572 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 13,725 Value ($000) $605 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 24,225 Value ($000) $1,219 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 24,725 Value ($000) $1,254 Avg Close $52.38 Range $43.75 - $60.01

Q2 2017

Shares 25,675 Value ($000) $1,306 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 26,125 Value ($000) $1,050 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 30,125 Value ($000) $1,441 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 30,125 Value ($000) $1,104 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 30,125 Value ($000) $702 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 38,625 Value ($000) $1,564 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 39,125 Value ($000) $2,423 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2018	13,725	$572	$44.30	$39.07 - $51.00
Q1 2018	13,725	$605	$50.80	$43.38 - $56.47
Q4 2017	24,225	$1,219	$54.84	$50.02 - $65.51
Q3 2017	24,725	$1,254	$52.38	$43.75 - $60.01
Q2 2017	25,675	$1,306	$46.57	$37.26 - $55.73
Q1 2017	26,125	$1,050	$44.91	$37.29 - $56.91
Q4 2016	30,125	$1,441	$39.57	$24.58 - $57.00
Q3 2016	30,125	$1,104	$31.29	$23.26 - $40.82
Q2 2016	30,125	$702	$32.26	$19.59 - $46.75
Q1 2016	38,625	$1,564	$40.62	$30.93 - $62.68
Q4 2015	39,125	$2,423	$53.96	$38.30 - $65.34