IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

COMMERZBANK AKTIENGESELLSCHAFT /FI's Holding History (CIK: 0000852933)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016

Shares 8,966 Value ($000) $209 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 8,826 Value ($000) $357 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 9,350 Value ($000) $579 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2016	8,966	$209	$32.26	$19.59 - $46.75
Q1 2016	8,826	$357	$40.62	$30.93 - $62.68
Q4 2015	9,350	$579	$53.96	$38.30 - $65.34