IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Washington Trust Bank's Holding History (CIK: 0000861787)

Note: Option positions (PUT/CALL) are excluded.

Q4 2017

Shares 58 Value ($000) $3 Avg Close $54.84 Range $50.02 - $65.51

Q4 2016

Shares 20 Value ($000) $1 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 20 Value ($000) $1 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 26 Value ($000) $1 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 26 Value ($000) $1 Avg Close $40.62 Range $30.93 - $62.68

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2017	58	$3	$54.84	$50.02 - $65.51
Q4 2016	20	$1	$39.57	$24.58 - $57.00
Q3 2016	20	$1	$31.29	$23.26 - $40.82
Q2 2016	26	$1	$32.26	$19.59 - $46.75
Q1 2016	26	$1	$40.62	$30.93 - $62.68