IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

DAVENPORT & Co LLC's Holding History (CIK: 0000887777)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 217,897 Value ($000) $17,238 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 62,563 Value ($000) $4,093 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 64,843 Value ($000) $2,562 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 56,393 Value ($000) $1,701 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 62,740 Value ($000) $2,193 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 75,598 Value ($000) $3,028 Avg Close $46.53 Range $39.48 - $52.34

Q2 2024

Shares 80,678 Value ($000) $3,845 Avg Close $41.01 Range $35.95 - $47.86

Q1 2024

Shares 83,928 Value ($000) $3,638 Avg Close $47.67 Range $41.60 - $54.44

Q4 2023

Shares 86,328 Value ($000) $4,367 Avg Close $47.90 Range $41.84 - $52.27

Q3 2023

Shares 86,877 Value ($000) $3,941 Avg Close $41.26 Range $38.26 - $47.72

Q2 2023

Shares 87,817 Value ($000) $3,603 Avg Close $38.43 Range $34.32 - $43.55

Q1 2023

Shares 80,617 Value ($000) $2,881 Avg Close $37.55 Range $32.69 - $41.73

Q4 2022

Shares 80,617 Value ($000) $3,045 Avg Close $42.06 Range $36.69 - $47.74

Q3 2022

Shares 84,863 Value ($000) $3,753 Avg Close $42.14 Range $35.95 - $48.82

Q2 2022

Shares 83,318 Value ($000) $3,084 Avg Close $37.71 Range $31.46 - $44.42

Q1 2022

Shares 83,863 Value ($000) $3,106 Avg Close $32.73 Range $28.25 - $37.15

Q4 2021

Shares 84,663 Value ($000) $2,576 Avg Close $31.48 Range $25.04 - $35.80

Q3 2021

Shares 122,303 Value ($000) $4,100 Avg Close $37.68 Range $33.52 - $40.99

Q2 2021

Shares 116,963 Value ($000) $4,663 Avg Close $39.17 Range $34.43 - $47.87

Q1 2021

Shares 124,738 Value ($000) $5,608 Avg Close $55.77 Range $41.42 - $64.37

Q4 2020

Shares 122,138 Value ($000) $6,906 Avg Close $49.83 Range $45.09 - $60.95

Q3 2020

Shares 122,538 Value ($000) $5,814 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 126,576 Value ($000) $7,463 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 136,826 Value ($000) $6,469 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 215,912 Value ($000) $13,043 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 146,166 Value ($000) $9,394 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 146,166 Value ($000) $9,394 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 174,802 Value ($000) $14,189 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 225,967 Value ($000) $12,216 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 214,959 Value ($000) $11,088 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 180,937 Value ($000) $7,540 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 98,690 Value ($000) $4,350,255 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 62,145 Value ($000) $3,125,894 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 32,900 Value ($000) $1,668,030 Avg Close $52.38 Range $43.75 - $60.01

Q2 2017

Shares 90,518 Value ($000) $4,604,651 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 26,500 Value ($000) $1,267,495 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 26,660 Value ($000) $1,275 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 28,160 Value ($000) $1,031,782 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 28,760 Value ($000) $669,820 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 28,560 Value ($000) $1,156,680 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 28,077 Value ($000) $1,738,809 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	217,897	$17,238	$75.30	$64.93 - $83.61
Q3 2025	62,563	$4,093	$48.82	$39.72 - $65.55
Q2 2025	64,843	$2,562	$32.73	$23.95 - $40.61
Q1 2025	56,393	$1,701	$32.75	$29.61 - $35.48
Q4 2024	62,740	$2,193	$37.38	$33.33 - $40.58
Q3 2024	75,598	$3,028	$46.53	$39.48 - $52.34
Q2 2024	80,678	$3,845	$41.01	$35.95 - $47.86
Q1 2024	83,928	$3,638	$47.67	$41.60 - $54.44
Q4 2023	86,328	$4,367	$47.90	$41.84 - $52.27
Q3 2023	86,877	$3,941	$41.26	$38.26 - $47.72
Q2 2023	87,817	$3,603	$38.43	$34.32 - $43.55
Q1 2023	80,617	$2,881	$37.55	$32.69 - $41.73
Q4 2022	80,617	$3,045	$42.06	$36.69 - $47.74
Q3 2022	84,863	$3,753	$42.14	$35.95 - $48.82
Q2 2022	83,318	$3,084	$37.71	$31.46 - $44.42
Q1 2022	83,863	$3,106	$32.73	$28.25 - $37.15
Q4 2021	84,663	$2,576	$31.48	$25.04 - $35.80
Q3 2021	122,303	$4,100	$37.68	$33.52 - $40.99
Q2 2021	116,963	$4,663	$39.17	$34.43 - $47.87
Q1 2021	124,738	$5,608	$55.77	$41.42 - $64.37
Q4 2020	122,138	$6,906	$49.83	$45.09 - $60.95
Q3 2020	122,538	$5,814	$55.55	$47.19 - $63.49
Q2 2020	126,576	$7,463	$55.63	$45.12 - $61.24
Q1 2020	136,826	$6,469	$55.74	$39.32 - $64.34
Q4 2019	215,912	$13,043	$59.58	$53.34 - $66.22
Q3 2019	146,166	$9,394	$65.17	$58.48 - $73.09
Q2 2019	146,166	$9,394	$70.69	$61.91 - $86.58
Q1 2019	174,802	$14,189	$64.51	$52.45 - $81.59
Q4 2018	225,967	$12,216	$51.00	$43.27 - $59.81
Q3 2018	214,959	$11,088	$46.98	$41.05 - $54.85
Q2 2018	180,937	$7,540	$44.30	$39.07 - $51.00
Q1 2018	98,690	$4,350,255	$50.80	$43.38 - $56.47
Q4 2017	62,145	$3,125,894	$54.84	$50.02 - $65.51
Q3 2017	32,900	$1,668,030	$52.38	$43.75 - $60.01
Q2 2017	90,518	$4,604,651	$46.57	$37.26 - $55.73
Q1 2017	26,500	$1,267,495	$44.91	$37.29 - $56.91
Q4 2016	26,660	$1,275	$39.57	$24.58 - $57.00
Q3 2016	28,160	$1,031,782	$31.29	$23.26 - $40.82
Q2 2016	28,760	$669,820	$32.26	$19.59 - $46.75
Q1 2016	28,560	$1,156,680	$40.62	$30.93 - $62.68
Q4 2015	28,077	$1,738,809	$53.96	$38.30 - $65.34